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Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries

Drakeley, Chris and Abdulla, Salim and Agnandji, Selidji Todagbe and Fernandes, José Francisco and Kremsner, Peter and Lell, Bertrand and Mewono, Ludovic and Bache, Bache Emmanuel and Mihayo, Michael Gabriel and Juma, Omar and Tanner, Marcel and Tahita, Marc Christian and Tinto, Halidou and Diallo, Salou and Lompo, Palpouguini and D'Alessandro, Umberto and Ogutu, Bernhards and Otieno, Lucas and Otieno, Solomon and Otieno, Walter and Oyieko, Janet and Asante, Kwaku Poku and Dery, Dominic Bon-Ereme and Adjei, George and Adeniji, Elisha and Atibilla, Dorcas and Owusu-Agyei, Seth and Greenwood, Brian and Gesase, Samwel and Lusingu, John and Mahende, Coline and Mongi, Robert and Segeja, Method and Adjei, Samuel and Agbenyega, Tsiri and Agyekum, Alex and Ansong, Daniel and Bawa, John Tanko and Boateng, Harry Owusu and Dandalo, Léonard and Escamilla, Veronica and Hoffman, Irving and Maenje, Peter and Martinson, Francis and Carter, Terrell and Leboulleux, Didier and Kaslow, David C. and Usuf, Effua and Pirçon, Jean-Yves and Bahmanyar, Edith Roset. (2017) Longitudinal estimation of Plasmodium falciparum prevalence in relation to malaria prevention measures in six sub-Saharan African countries. Malaria journal, 16. p. 433.

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Abstract

Plasmodium falciparum prevalence (PfPR) is a widely used metric for assessing malaria transmission intensity. This study was carried out concurrently with the RTS,S/AS01 candidate malaria vaccine Phase III trial and estimated PfPR over ≤ 4 standardized cross-sectional surveys.; This epidemiology study (NCT01190202) was conducted in 8 sites from 6 countries (Burkina Faso, Gabon, Ghana, Kenya, Malawi, and Tanzania), between March 2011 and December 2013. Participants were enrolled in a 2:1:1 ratio according to age category: 6 months-4 years, 5-19 years, and ≥ 20 years, respectively, per year and per centre. All sites carried out surveys 1-3 while survey 4 was conducted only in 3 sites. Surveys were usually performed during the peak malaria parasite transmission season, in one home visit, when medical history and malaria risk factors/prevention measures were collected, and a blood sample taken for rapid diagnostic test, microscopy, and haemoglobin measurement. PfPR was estimated by site and age category.; Overall, 6401 (survey 1), 6411 (survey 2), 6400 (survey 3), and 2399 (survey 4) individuals were included in the analyses. In the 6 months-4 years age group, the lowest prevalence (assessed using microscopy) was observed in 2 Tanzanian centres (4.6% for Korogwe and 9.95% for Bagamoyo) and Lambaréné, Gabon (6.0%), while the highest PfPR was recorded for Nanoro, Burkina Faso (52.5%). PfPR significantly decreased over the 3 years in Agogo (Ghana), Kombewa (Kenya), Lilongwe (Malawi), and Bagamoyo (Tanzania), and a trend for increased PfPR was observed over the 4 surveys for Kintampo, Ghana. Over the 4 surveys, for all sites, PfPR was predominantly higher in the 5-19 years group than in the other age categories. Occurrence of fever and anaemia was associated with high P. falciparum parasitaemia. Univariate analyses showed a significant association of anti-malarial treatment in 4 surveys (odds ratios [ORs]: 0.52, 0.52, 0.68, 0.41) and bed net use in 2 surveys (ORs: 0.63, 0.68, 1.03, 1.78) with lower risk of malaria infection.; Local PfPR differed substantially between sites and age groups. In children 6 months-4 years old, a significant decrease in prevalence over the 3 years was observed in 4 out of the 8 study sites. Trial registration Clinical Trials.gov identifier: NCT01190202:NCT. GSK Study ID numbers: 114001.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Health Interventions > Malaria Vaccines (Tanner)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Tanner, Marcel
Item Type:Article, refereed
Publisher:BioMed Central.
ISSN:1475-2875
e-ISSN:1475-2875
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:08 Dec 2017 08:48
Deposited On:08 Dec 2017 08:47

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