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Biosynthesis of the antibiotic nematophin and its elongated derivatives in entomopathogenic bacteria

Cai, Xiaofeng and Challinor, Victoria L. and Zhao, Lei and Reimer, Daniela and Adihou, Hélène and Grün, Peter and Kaiser, Marcel and Bode, Helge B.. (2017) Biosynthesis of the antibiotic nematophin and its elongated derivatives in entomopathogenic bacteria. Organic letters, 19 (4). pp. 806-809.

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Official URL: http://edoc.unibas.ch/54723/

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Abstract

Nematophin, a known antibiotic natural product against Staphylococcus aureus for almost 20 years, is produced by all strains of Xenorhabdus nematophila. Despite its simple structure, its biosynthesis was unknown. Its biosynthetic pathway is reported using heterologous production in Escherichia coli. Additionally, the identification, structure elucidation, and biosynthesis of six extended nematophin derivatives from Xenorhabdus PB62.4 carrying an additional valine are reported. Preliminary bioactivity studies suggest a biological role of these compounds in the bacteria-nematode-insect symbiosis.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Parasite Chemotherapy (Mäser)
UniBasel Contributors:Kaiser, Marcel
Item Type:Article, refereed
Publisher:American Chemical Society
ISSN:1523-7060
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:29 May 2017 11:45
Deposited On:29 May 2017 11:45

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