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Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011 : a case series

Badirzadeh, Alireza and Mohebali, Mehdi and Ghasemian, Mehrdad and Amini, Hassan and Zarei, Zabiholah and Akhoundi, Behnaz and Hajjaran, Homa and Emdadi, Dariush and Molaei, Soheila and Kusha, Ahmad and Alizadeh, Saber. (2013) Cutaneous and post kala-azar dermal leishmaniasis caused by Leishmania infantum in endemic areas of visceral leishmaniasis, northwestern Iran 2002-2011 : a case series. Pathogens and Global health, 107 (4). pp. 194-197.

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Official URL: http://edoc.unibas.ch/50725/

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Abstract

Visceral leishmaniasis (VL) is endemic in Northwest and southern Iran. Reports of cutaneous leishmaniasis (CL) in Northwest areas are rare, and its etiological agents are unknown. In the current study, we report six CL and two post kala-azar dermal leishmaniasis (PKDL) cases caused by Leishmania infantum from endemic areas of VL in the Northwest. Smears were made from skin lesions of 30 suspected patients in 2002-2011, and CL was determined by microscopy or culture. Leishmania spp. were identified by nested-PCR assay. The disease was confirmed in 20 out of 30 (66%) suspected patients by parasitological examinations. L. infantum was identified in eight and Leishmania major in 12 CL cases by nested-PCR. Cutaneous leishmaniasis patients infected with L. major had the history of travel to CL endemic areas. L. infantum antibodies were detected by direct agglutination test (DAT) at titers of 1:3200 in two cases with history of VL. Results of this study indicated that L. infantum is a causative agent of CL as well as PKDL in the VL endemic areas.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
UniBasel Contributors:Amini, Hassan
Item Type:Article, refereed
Publisher:Maney
ISSN:2047-7724
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:21 Feb 2017 10:59
Deposited On:21 Feb 2017 10:59

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