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Bimodal x-ray and infrared imaging of an organometallic derivative of praziquantel in Schistosoma mansoni

Clède, Sylvain and Cowan, Noemi and Lambert, François and Bertrand, Hélène C. and Rubbiani, Riccardo and Patra, Malay and Hess, Jeannine and Sandt, Christophe and Trcera, Nicolas and Gasser, Gilles and Keiser, Jennifer and Policar, Clotilde. (2016) Bimodal x-ray and infrared imaging of an organometallic derivative of praziquantel in Schistosoma mansoni. ChemBioChem, 17 (11). pp. 1004-1007.

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Official URL: http://edoc.unibas.ch/44666/

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Abstract

An organometallic derivative of praziquantel was studied directly in worms by using inductively coupled plasma-mass spectrometry (ICP-MS) for quantification and synchrotron-based imaging. X-ray fluorescence (XRF) and IR absorption spectromicroscopy were used for the first time in combination to directly locate this organometallic drug candidate in schistosomes. The detection of both CO (IR) and Cr (XRF) signatures proved that the Cr(CO)3 core remained intact in the worms. Images showed a preferential accumulation at the worm's tegument, consistent with a possible targeting of the calcium channel but not excluding other biological targets inside the worm.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Helminth Drug Development (Keiser)
UniBasel Contributors:Keiser, Jennifer
Item Type:Article, refereed
Publisher:Wiley-VCH
ISSN:1439-4227
e-ISSN:1439-7633
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:01 Dec 2016 13:14
Deposited On:01 Dec 2016 13:14

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