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Heart rate, heart rate variability and inflammatory biomarkers among young and healthy adults

Aeschbacher, Stefanie and Schoen, Tobias and Dörig, Laura and Kreuzmann, Rahel and Neuhauser, Charlotte and Schmidt-Trucksäss, Arno and Probst-Hensch, Nicole M. and Risch, Martin and Risch, Lorenz and Conen, David. (2017) Heart rate, heart rate variability and inflammatory biomarkers among young and healthy adults. Annals of medicine, 49 (1). pp. 32-41.

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Official URL: http://edoc.unibas.ch/44212/

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Abstract

Heart rate (HR), heart rate variability (HRV) and inflammation are all associated with cardiovascular morbidity and mortality. The aim of this study was to assess potential interrelationships between these parameters in a young and healthy population.; Healthy individuals aged 25-41 years were included in a prospective population-based study. All participants underwent 24-hour electrocardiography using a validated device. The standard deviation of all normal RR intervals (SDNN) was pre-defined as the main HRV outcome variable. High-sensitivity C-reactive protein (hs-CRP), total leukocyte (LC) count and LC subtypes were obtained from venous blood samples.; 2064 participants (47% men, 37years) were included in this analysis. In multivariable linear regression analyses using SDNN as the outcome variable, β-coefficients (95% confidence intervals) per 1 standard deviation (SD) increase on the log-scale were -0.11 (-0.16;-0.07),p < 0.0001 for hs-CRP, -0.13 (-0.17;-0.09),p < 0.0001 for total LC count, -0.12 (-0.16;-0.08),p < 0.0001 for neutrophils, -0.04 (-0.09;0.00),p = 0.05 for lymphocytes and -0.08 (-0.09;-0.02),p = 0.005 for monocytes. There were positive relationships between resting and ambulatory HR and inflammatory biomarkers, except for lymphocytes.; In this large cohort of young and healthy adults, inflammatory parameters were strongly associated with increased HR and decreased HRV, suggesting an important interaction between inflammatory pathways and the autonomic nervous system.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Chronic Disease Epidemiology > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
03 Faculty of Medicine > Departement Public Health > Sozial- und Präventivmedizin > Genetic Epidemiology of Non-Communicable Diseases (Probst-Hensch)
UniBasel Contributors:Probst Hensch, Nicole
Item Type:Article, refereed
Publisher:The Finnish Medical Society Duodecim
ISSN:0785-3890
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:20 Apr 2017 11:02
Deposited On:20 Apr 2017 11:02

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