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How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis - designing a prospective observational study in South Africa

Kastien-Hilka, Tanja and Rosenkranz, Bernd and Bennett, Bryan and Sinanovic, Edina and Schwenkglenks, Matthias. (2016) How to evaluate health-related quality of life and its association with medication adherence in pulmonary tuberculosis - designing a prospective observational study in South Africa. Frontiers in pharmacology, 6. p. 125.

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Official URL: http://edoc.unibas.ch/43593/

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Abstract

Health-related quality of life (HRQOL) has become an important measure to identify and shape effective and patient-relevant healthcare interventions innovations through outcomes. Adherence to tuberculosis (TB) treatment is a public health concern. The main objective of this research is to develop a study design for evaluation of HRQOL and its association with medication adherence in TB in South Africa.; A conceptual framework for HRQOL in TB has been developed to identify Patient-Reported Outcomes and Quality of Life Database (PROQOLID), (n.d.) measures for HRQOL and adherence and to generate an endpoint model. Two generic (SF-12 and EQ-5D-5L), one disease-specific (St. George's Respiratory Questionnaire) and one condition-specific (Hospital Anxiety and Depression Scale) measure for HRQOL and Morisky Medication Adherence Scale for adherence assessment were identified. All measures are applied in a longitudinal multi-center study at five data collection time points during standard TB treatment. Statistical analysis includes multivariable analysis. Change over time in the physical component score of SF-12 is defined as primary endpoint. Sample size estimation based thereupon has led to a recruitment target of 96 patients. This study is on-going.; This is the first longitudinal study in South Africa which evaluates HRQOL and its association with medication adherence in TB in a comprehensive manner. Results will help to improve current treatment programs and medication adherence and will support the identification of sustainable health innovations in TB, determining the value of new products, and supporting decision making with regard to health policy and pricing.
Faculties and Departments:03 Faculty of Medicine > Departement Public Health > Pharmazeutische Medizin ECPM > Pharmazeutische Medizin (Szucs)
UniBasel Contributors:Schwenkglenks, Matthias
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Frontiers Media
ISSN:1663-9812
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:03 Jan 2017 07:34
Deposited On:03 Jan 2017 07:34

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