Goncharenko, Kristina and Seebeck, Florian P.. (2016) Conversion of a non-heme iron-dependent sulfoxide synthase into a thiol dioxygenase by a single point mutation. Chemical Communications , 52 (9). pp. 1945-1948.
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Abstract
EgtB from Mycobacterium thermoresistibile catalyzes O2-dependent sulfur-carbon bond formation between the side chains of Nα-trimethyl histidine and γ-glutamyl cysteine as a central step in ergothioneine biosynthesis. A single point mutation converts this enzyme into a γ-glutamyl cysteine dioxygenase with an efficiency that rivals naturally evolved thiol dioxygenases.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Molecular Bionics (Seebeck) |
|---|---|
| UniBasel Contributors: | Seebeck, Florian Peter |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| e-ISSN: | 1364-548X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 28 Nov 2016 14:56 |
| Deposited On: | 25 Apr 2016 13:07 |
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