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Lab-on-chip-based platform for fast molecular diagnosis of multidrug-resistant tuberculosis

Cabibbe, Andrea M. and Miotto, Paolo and Moure, Raquel and Alcaide, Fernando and Feuerriegel, Silke and Pozzi, Gianni and Nikolayevskyy, Vladislav and Drobniewski, Francis and Niemann, Stefan and Reither, Klaus and Cirillo, Daniela M.. (2015) Lab-on-chip-based platform for fast molecular diagnosis of multidrug-resistant tuberculosis. Journal of clinical microbiology, 53 (12). pp. 3876-3880.

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Official URL: http://edoc.unibas.ch/39878/

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Abstract

We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.
Faculties and Departments:09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH)
09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology > Tuberculosis Research (Gagneux)
UniBasel Contributors:Reither, Klaus
Item Type:Article, refereed
ISSN:1098-660X
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:30 Jun 2016 11:00
Deposited On:27 Jan 2016 14:32

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