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Benzo(a)pyrene Metabolism and EROD and GST Biotransformation Activity in the Liver of Red- and White-Blooded Antarctic Fish

Strobel, Anneli and Burkhardt-Holm, Patricia and Schmid, Peter and Segner, Helmut. (2015) Benzo(a)pyrene Metabolism and EROD and GST Biotransformation Activity in the Liver of Red- and White-Blooded Antarctic Fish. Environmental Science and Technology, 49 (13). pp. 8022-8032.

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Abstract

Climate change and anthropogenic pollution are of increasingconcern in remote areas such as Antarctica. The evolutionary adaptation ofAntarctic notothenioid fish to the cold and stable Southern Ocean led to a lowplasticity of their physiological functions, what may limit their capacity to dealwith altered temperature regimes and pollution in the Antarctic environment.Using a biochemical approach, we aimed to assess the hepaticbiotransformation capacities of Antarctic fish species by determining (i) theactivities of ethoxyresorufin-O-deethylase (EROD) and glutathione-S-transferase(GST), and (ii) the metabolic clearance of benzo(a)pyrene by hepaticS9 supernatants. In addition, we determined the thermal sensitivity of thexenobiotic biotransformation enzymes. We investigated the xenobioticmetabolism of the red-blooded Gobionotothen gibberif rons and Nototheniarossii, the hemoglobin-less Chaenocephalus aceratus and Champsocephalusgunnari, and the rainbow trout Oncorhynchus mykiss as a reference. Our results revealed similar metabolic enzyme activities andmetabolic clearance rates between red- and white-blooded Antarctic fish, but significantly lower rates in comparison to rainbowtrout. Therefore, bioaccumulation factors for metabolizable lipophilic contaminants may be higher in Antarctic than in temperatefish. Likewise, the thermal adaptive capacities and flexibilities of the EROD and GST activities in Antarctic fish were significantlylower than in rainbow trout. As a consequence, increasing water temperatures in the Southern Ocean will additionallycompromise the already low detoxification capacities of Antarctic fish.
Faculties and Departments:05 Faculty of Science > Departement Umweltwissenschaften > Mensch Gesellschaft Umwelt MGU > Aquatische ├ľkologie (Holm)
UniBasel Contributors:Holm, Patricia and Strobel, Anneli
Item Type:Article, refereed
Publisher:American Chemical Society
ISSN:0013-936X
e-ISSN:1520-5851
Note:Publication type according to Uni Basel Research Database: Journal article -- The final, edited publication is available via DOI link.
Language:English
Identification Number:
Last Modified:12 Sep 2017 08:35
Deposited On:04 Feb 2016 10:59

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