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Prospective surveillance of hospitalisations associated with varicella-zoster virus infections in children and adolescents

Bonhoeffer, J. and Baer, G. and Muehleisen, B. and Aebi, C. and Nadal, D. and Schaad, U. B. and Heininger, U.. (2005) Prospective surveillance of hospitalisations associated with varicella-zoster virus infections in children and adolescents. European journal of pediatrics, Vol. 164, H. 6. S. 366-370.

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Official URL: http://edoc.unibas.ch/dok/A5838831

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Abstract

Our goal was to determine the epidemiology of severe varicella-zoster virus (VZV) infections in hospitalised paediatric patients. Admissions associated with VZV infection of patients aged 0-16 years were reported by all 38 paediatric units in Switzerland to the Swiss Paediatric Surveillance Unit (SPSU) during 3 consecutive years (4/2000-3/2003). We verified completeness of reporting by capture-recapture analysis with patient records identified by ICD-10 codes. Outcome of illness was assessed 6 months after hospitalisation. A total of 335 cases (235 identified by SPSU reports, 100 by ICD-10 code) were included in this study. Mean age of patients was 4.1 years (median 3.5 years, range 0-16 years); 54 chickenpox, 42 (13 not immunocompromised. A total of 319 complications occurred in 237 (71 nervous system involvement (n = 76); VZV pneumonitis (n = 7); others (n = 127). Eleven (3 On follow-up, 303 (96 sequelae were present in 12 (4 hospitalisation rate was 13 per 104 cases. Conclusion: This study describes a sizeable hospitalisation and complication rate of varicella-zoster virus infections and provides a solid basis for future immunisation recommendations in Switzerland.
Faculties and Departments:03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB)
03 Faculty of Medicine
UniBasel Contributors:Heininger, Ulrich
Item Type:Article, refereed
Bibsysno:Link to catalogue
Publisher:Springer
ISSN:1432-1076
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:08 Jun 2012 06:53
Deposited On:08 Jun 2012 06:29

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