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Development of novel, potent and selective small molecular weight PI3K/mTOR inhibitors for the treatment of cancer

Cmiljanović, Nataša. Development of novel, potent and selective small molecular weight PI3K/mTOR inhibitors for the treatment of cancer. 2011, PhD Thesis, University of Basel, Faculty of Science.

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Official URL: http://edoc.unibas.ch/diss/DissB_9393

Abstract

The phosphoinositide 3-kinases (PI3Ks) belong to a family of lipid kinases, which are implicated in signal transduction pathways and modulation of fundamental cellular activities such as cell growth, proliferation, differentiation, motility, survival and metabolism. The involvement of PI3Ks in such important biological processes can lead in case of their deregulation to development of various diseases including diabetes, thrombosis, inflammatory and autoimmune diseases as well as cancer. In recent years, PI3Ks have become extremely attractive target of industry and the academy as well. This contributed to the development of a numerous PI3K inhibitors and many of them have established the potential usefulness as therapeutics for treatment of cancer.
Advisors:Giese, Bernd
Committee Members:Constable, Edwin C.
Faculties and Departments:05 Faculty of Science > Departement Chemie > Former Organization Units Chemistry > Bioorganische Chemie (Giese)
Item Type:Thesis
Thesis no:9393
Bibsysno:Link to catalogue
Number of Pages:121 S.
Language:English
Identification Number:
Last Modified:30 Jun 2016 10:41
Deposited On:11 Mar 2011 08:50

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