Items where Author is "Okombo, John"

2019

Okombo, John and Brunschwig, Christel and Singh, Kawaljit and Dziwornu, Godwin Akpeko and Barnard, Linley and Njoroge, Mathew and Wittlin, Sergio and Chibale, Kelly. (2019) Antimalarial pyrido[1,2-a]benzimidazole derivatives with mannich base side chains: synthesis, pharmacological evaluation and reactive metabolite trapping studies. ACS infectious diseases, 5 (3). pp. 372-384.

Kumar, Malkeet and Okombo, John and Mambwe, Dickson and Taylor, Dale and Lawrence, Nina and Reader, Janette and van der Watt, Mariëtte and Fontinha, Diana and Sanches-Vaz, Margarida and Bezuidenhout, Belinda C. and Lauterbach, Sonja B. and Liebenberg, Dale and Birkholtz, Lyn-Marie and Coetzer, Theresa L. and Prudêncio, Miguel and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2019) Multistage antiplasmodium activity of astemizole analogues and inhibition of hemozoin formation as a contributor to their mode of action. ACS infectious diseases, 5 (2). pp. 303-315.

Mayoka, Godfrey and Njoroge, Mathew and Okombo, John and Gibhard, Liezl and Sanches-Vaz, Margarida and Fontinha, Diana and Birkholtz, Lyn-Marie and Reader, Janette and van der Watt, Mariëtte and Coetzer, Theresa L. and Lauterbach, Sonja and Churchyard, Alisje and Bezuidenhout, Belinda and Egan, Timothy J. and Yeates, Clive Leonard and Wittlin, Sergio and Prudêncio, Miguel and Chibale, Kelly. (2019) Structure-activity relationship studies and Plasmodium life cycle profiling identifies pan-active N-aryl-3-trifluoromethyl pyrido[1,2-a]benzimidazoles which are efficacious in an in vivo mouse model of malaria. Journal of medicinal chemistry, 62 (2). pp. 1022-1035.

2017

Singh, Kawaljit and Okombo, John and Brunschwig, Christel and Ndubi, Ferdinand and Barnard, Linley and Wilkinson, Chad and Njogu, Peter M. and Njoroge, Mathew and Laing, Lizahn and Machado, Marta and Prudêncio, Miguel and Reader, Janette and Botha, Mariette and Nondaba, Sindisiwe and Birkholtz, Lyn-Marie and Lauterbach, Sonja and Churchyard, Alisje and Coetzer, Theresa L. and Burrows, Jeremy N. and Yeates, Clive and Denti, Paolo and Wiesner, Lubbe and Egan, Timothy J. and Wittlin, Sergio and Chibale, Kelly. (2017) Antimalarial pyrido[1,2-a]benzimidazoles : lead optimization, parasite life cycle stage profile, mechanistic evaluation, killing kinetics, and in vivo oral efficacy in a mouse model. Journal of medicinal chemistry, 60 (4). pp. 1432-1448.

Okombo, John and Singh, Kawaljit and Mayoka, Godfrey and Ndubi, Ferdinand and Barnard, Linley and Njogu, Peter M. and Njoroge, Mathew and Gibhard, Liezl and Brunschwig, Christel and Vargas, Mireille and Keiser, Jennifer and Egan, Timothy J. and Chibale, Kelly. (2017) Antischistosomal activity of pyrido[1,2-a]benzimidazole derivatives and correlation with inhibition of beta-hematin formation. ACS Infectious Diseases, 3 (6). pp. 411-420.

Espinoza-Moraga, Marlene and Singh, Kawaljit and Njoroge, Mathew and Kaur, Gurminder and Okombo, John and De Kock, Carmen and Smith, Peter J. and Wittlin, Sergio and Chibale, Kelly. (2017) Synthesis and biological characterisation of ester and amide derivatives of fusidic acid as antiplasmodial agents. Bioorganic & medicinal chemistry, 27 (3). pp. 658-661.