edoc

Browse by Basel Contributors ID

Up a level
Export as [feed] Atom [feed] RSS 1.0 [feed] RSS 2.0
Group by: Date | Item Type | Refereed | No Grouping
Jump to: 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010

2023

Colina-Vegas, L. and da Cruz, B. Silva M. and de Souza Pereira, C. and Isis Barros, A. and Araújo Nobrega, J. and Navarro, M. and Rottmann, M. and D'Alessandro, S. and Basilico, N. and Azevedo Batista, A. and Moreira, D. R. M.. (2023) Antimalarial agents derived from metal-amodiaquine complexes with activity in multiple stages of the plasmodium life cycle. Chemistry, 29 (55). e202301642.

2022

Hirsch, A. K. H. and Diamanti, E. and Hamed, M. M. and Lacour, A. and Bravo, P. and Illarionov, B. and Fischer, M. and Rottmann, M. and Witschel, M.. (2022) Targeting the IspD enzyme in the MEP pathway: identification of a novel fragment class. ChemMedChem, 17. e202100679.

Khandelwal, A. and Arez, F. and Alves, P. M. and Badolo, L. and Brito, C. and Fischli, C. and Fontinha, D. and Oeuvray, C. and Prudêncio, M. and Rottmann, M. and Wilkins, J. and Yalkinoglu, Ö. and Bagchus, W. M. and Spangenberg, T.. (2022) Translation of liver stage activity of M5717, a; Plasmodium; elongation factor 2 inhibitor: from bench to bedside. Malar J, 21. p. 151.

Lowe, M. A. and Cardenas, A. and Valentin, J. P. and Zhu, Z. and Abendroth, J. and Castro, J. L. and Class, R. and Delaunois, A. and Fleurance, R. and Gerets, H. and Gryshkova, V. and King, L. and Lorimer, D. D. and MacCoss, M. and Rowley, J. H. and Rosseels, M. L. and Royer, L. and Taylor, R. D. and Wong, M. and Zaccheo, O. and Chavan, V. P. and Ghule, G. A. and Tapkir, B. K. and Burrows, J. N. and Duffey, M. and Rottmann, M. and Wittlin, S. and Angulo-Barturen, I. and Jiménez-Díaz, M. B. and Striepen, J. and Fairhurst, K. J. and Yeo, T. and Fidock, D. A. and Cowman, A. F. and Favuzza, P. and Crespo-Fernandez, B. and Gamo, F. J. and Goldberg, D. E. and Soldati-Favre, D. and Laleu, B. and de Haro, T.. (2022) Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of UCB7362. Journal of medicinal chemistry, 65 (20). pp. 14121-14143.

Radohery, G. F. R. and Walz, A. and Gumpp, C. and Cherkaoui-Rbati, M. H. and Gobeau, N. and Gower, J. and Davenport, M. P. and Rottmann, M. and McCarthy, J. S. and Möhrle, J. J. and Rebelo, M. and Demarta-Gatsi, C. and Khoury, D. S.. (2022) Parasite viability as a measure of in vivo drug activity in preclinical and early clinical antimalarial drug assessment. Antimicrob Agents Chemother, 66 (7). e0011422.

Wicha, S. G. and Walz, A. and Cherkaoui-Rbati, M. H. and Bundgaard, N. and Kuritz, K. and Gumpp, C. and Gobeau, N. and Möhrle, J. and Rottmann, M. and Demarta-Gatsi, C.. (2022) New in vitro interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations. Antimicrob Agents Chemother, 66 (11). e0055622.

2021

Ropponen, H. K. and Diamanti, E. and Siemens, A. and Illarionov, B. and Haupenthal, J. and Fischer, M. and Rottmann, M. and Witschel, M. and Hirsch, A. K. H.. (2021) Assessment of the rules related to gaining activity against gram-negative bacteria. RSC Med Chem, 12 (4). pp. 593-601.

Ropponen, H. K. and Bader, C. D. and Diamanti, E. and Illarionov, B. and Rottmann, M. and Fischer, M. and Witschel, M. and Müller, R. and Hirsch, A. K. H.. (2021) Search for the active ingredients from a 2-aminothiazole DMSO stock solution with antimalarial activity. ChemMedChem, 16. pp. 2089-2093.

2020

Burgert, Lydia and Rottmann, Matthias and Wittlin, Sergio and Gobeau, Nathalie and Krause, Andreas and Dingemanse, Jasper and Möhrle, Jörg J. and Penny, Melissa A.. (2020) Ensemble modeling highlights importance of understanding parasite-host behavior in preclinical antimalarial drug development. Scientific reports, 10. p. 4410.

Rottmann, Matthias and Jonat, Brian and Gumpp, Christin and Dhingra, Satish K. and Giddins, Marla J. and Yin, Xiaoyan and Badolo, Lassina and Greco, Beatrice and Fidock, David A. and Oeuvray, Claude and Spangenberg, Thomas. (2020) Preclinical antimalarial combination studies: the case of M5717, a P. falciparum elongation factor 2 inhibitor and pyronaridine, a hemozoin formation inhibitor. Antimicrobial agents and chemotherapy, 64 (4). e02181-19.

Mueller, Rudolf and Reddy, Virsinha and Nchinda, Aloysius T. and Mebrahtu, Fanuel and Taylor, Dale and Lawrence, Nina and Tanner, Lloyd and Barnabe, Marine and Eyermann, Charles J. and Zou, Bin and Kondreddi, Ravinder R. and Lakshminarayana, Suresh B. and Rottmann, Matthias and Street, Leslie J. and Chibale, Kelly. (2020) Lerisetron analogues with antimalarial properties: synthesis, structure-activity relationship studies, and biological assessment. ACS Omega, 5 (12). pp. 6967-6982.

Favuzza, Paola and de Lera Ruiz, Manuel and Thompson, Jennifer K. and Triglia, Tony and Ngo, Anna and Steel, Ryan W. J. and Vavrek, Marissa and Christensen, Janni and Healer, Julie and Boyce, Christopher and Guo, Zhuyan and Hu, Mengwei and Khan, Tanweer and Murgolo, Nicholas and Zhao, Lianyun and Penington, Jocelyn Sietsma and Reaksudsan, Kitsanapong and Jarman, Kate and Dietrich, Melanie H. and Richardson, Lachlan and Guo, Kai-Yuan and Lopaticki, Sash and Tham, Wai-Hong and Rottmann, Matthias and Papenfuss, Tony and Robbins, Jonathan A. and Boddey, Justin A. and Sleebs, Brad E. and Sabroux, Hélène Jousset and McCauley, John A. and Olsen, David B. and Cowman, Alan F.. (2020) Dual plasmepsin-targeting antimalarial agents disrupt multiple stages of the malaria parasite life cycle. Cell host & microbe, 27 (4). pp. 642-658.e12.

2019

Baragaña, Beatriz and Forte, Barbara and Choi, Ryan and Nakazawa Hewitt, Stephen and Bueren-Calabuig, Juan A. and Pisco, João Pedro and Peet, Caroline and Dranow, David M. and Robinson, David A. and Jansen, Chimed and Norcross, Neil R. and Vinayak, Sumiti and Anderson, Mark and Brooks, Carrie F. and Cooper, Caitlin A. and Damerow, Sebastian and Delves, Michael and Dowers, Karen and Duffy, James and Edwards, Thomas E. and Hallyburton, Irene and Horst, Benjamin G. and Hulverson, Matthew A. and Ferguson, Liam and Jiménez-Díaz, María Belén and Jumani, Rajiv S. and Lorimer, Donald D. and Love, Melissa S. and Maher, Steven and Matthews, Holly and McNamara, Case W. and Miller, Peter and O'Neill, Sandra and Ojo, Kayode K. and Osuna-Cabello, Maria and Pinto, Erika and Post, John and Riley, Jennifer and Rottmann, Matthias and Sanz, Laura M. and Scullion, Paul and Sharma, Arvind and Shepherd, Sharon M. and Shishikura, Yoko and Simeons, Frederick R. C. and Stebbins, Erin E. and Stojanovski, Laste and Straschil, Ursula and Tamaki, Fabio K. and Tamjar, Jevgenia and Torrie, Leah S. and Vantaux, Amélie and Witkowski, Benoît and Wittlin, Sergio and Yogavel, Manickam and Zuccotto, Fabio and Angulo-Barturen, Iñigo and Sinden, Robert and Baum, Jake and Gamo, Francisco-Javier and Mäser, Pascal and Kyle, Dennis E. and Winzeler, Elizabeth A. and Myler, Peter J. and Wyatt, Paul G. and Floyd, David and Matthews, David and Sharma, Amit and Striepen, Boris and Huston, Christopher D. and Gray, David W. and Fairlamb, Alan H. and Pisliakov, Andrei V. and Walpole, Chris and Read, Kevin D. and Van Voorhis, Wesley C. and Gilbert, Ian H.. (2019) Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proceedings of the National Academy of Sciences of the United States of America, 116 (14). pp. 7015-7020.

Arez, Francisca and Rebelo, Sofia P. and Fontinha, Diana and Simão, Daniel and Martins, Tatiana R. and Machado, Marta and Fischli, Christoph and Oeuvray, Claude and Badolo, Lassina and Carrondo, Manuel J. T. and Rottmann, Matthias and Spangenberg, Thomas and Brito, Catarina and Greco, Beatrice and Prudêncio, Miguel and Alves, Paula M.. (2019) Flexible 3D cell-based platforms for the discovery and profiling of novel drugs targeting plasmodium hepatic infection. ACS infectious diseases, 5 (11). pp. 1831-1842.

2018

Levatić, Jurica and Pavić, Kristina and Perković, Ivana and Uzelac, Lidija and Ester, Katja and Kralj, Marijeta and Kaiser, Marcel and Rottmann, Matthias and Supek, Fran and Zorc, Branka. (2018) Machine learning prioritizes synthesis of primaquine ureidoamides with high antimalarial activity and attenuated cytotoxicity. European journal of medicinal chemistry, 146. pp. 651-667.

Grogg, Marcel and Hilvert, Donald and Ebert, Marc-Olivier and Beck, Albert K. and Seebach, Dieter and Kurth, Felix and Dittrich, Petra S. and Sparr, Christof and Wittlin, Sergio and Rottmann, Matthias and Mäser, Pascal. (2018) Cell penetration, herbicidal activity, and in-vivo-toxicity of oligo-arginine derivatives and of novel guanidinium-rich compounds derived from the biopolymer cyanophycin. Helvetica Chimica Acta, 101 (10). e1800112.

Martí Coma-Cros, Elisabet and Biosca, Arnau and Marques, Joana and Carol, Laura and Urbán, Patricia and Berenguer, Diana and Riera, Maria Cristina and Delves, Michael and Sinden, Robert E. and Valle-Delgado, Juan José and Spanos, Lefteris and Siden-Kiamos, Inga and Pérez, Paula and Paaijmans, Krijn and Rottmann, Matthias and Manfredi, Amedea and Ferruti, Paolo and Ranucci, Elisabetta and Fernàndez-Busquets, Xavier. (2018) Polyamidoamine nanoparticles for the oral administration of antimalarial drugs. Pharmaceutics, 10 (4). p. 225.

Schwertz, Geoffrey and Witschel, Matthias C. and Rottmann, Matthias and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Jaruwat, Aritsara and Amornwatcharapong, Watcharee and Ittarat, Wanwipa and Schäfer, Anja and Aponte, Raphael A. and Trapp, Nils and Chaiyen, Pimchai and Diederich, François. (2018) Potent inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) featuring a spirocyclic scaffold. ChemMedChem, 13 (9). pp. 931-943.

2017

Schwertz, Geoffrey and Witschel, Matthias C. and Rottmann, Matthias and Bonnert, Roger and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Jaruwat, Aritsara and Ittarat, Wanwipa and Schäfer, Anja and Aponte, Raphael A. and Charman, Susan A. and White, Karen L. and Kundu, Abhijit and Sadhukhan, Surajit and Lloyd, Mel and Freiberg, Gail M. and Srikumaran, Myron and Siggel, Marc and Zwyssig, Adrian and Chaiyen, Pimchai and Diederich, François. (2017) Antimalarial inhibitors rargeting serine hydroxymethyltransferase (SHMT) with in vivo efficacy and analysis of their binding mode based on X-ray cocrystal structures. Journal of Medicinal Chemistry, 60 (12). pp. 4840-4860.

Schwertz, Geoffrey and Frei, Michelle S. and Witschel, Matthias C. and Rottmann, Matthias and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Jaruwat, Aritsara and Ittarat, Wanwipa and Schäfer, Anja and Aponte, Raphael A. and Trapp, Nils and Mark, Kerstin and Chaiyen, Pimchai and Diederich, François. (2017) Conformational aspects in the design of inhibitors for serine hydroxymethyltransferase (SHMT): biphenyl, aryl sulfonamide, and aryl sulfone motifs. Chemistry - A European Journal, 23 (57). pp. 14345-14357.

2016

Najer, Adrian and Wu, Dalin and Nussbaumer, Martin G. and Schwertz, Geoffrey and Schwab, Anatol and Witschel, Matthias C. and Schafer, Anja and Diederich, Francois and Rottmann, Matthias and Palivan, Cornelia G. and Beck, Hans-Peter and Meier, Wolfgang. (2016) An amphiphilic graft copolymer-based nanoparticle platform for reduction-responsive anticancer and antimalarial drug delivery. Nanoscale, 8. pp. 14858-14869.

2015

Lakshminarayana, Suresh B. and Freymond, Céline and Fischli, Christoph and Yu, Jing and Weber, Sebastian and Goh, Anne and Yeung, Bryan K. S. and Ho, Paul C. and Dartois, Véronique and Diagana, Thierry T. and Rottmann, Matthias and Blasco, Francesca. (2015) Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model. Antimicrobial agents and chemotherapy, Vol. 59, H. 2. pp. 1200-1210.

Witschel, Matthias C. and Rottmann, Matthias and Schwab, Anatol and Leartsakulpanich, Ubolsree and Chitnumsub, Penchit and Seet, Michael and Tonazzi, Sandro and Schwertz, Geoffrey and Stelzer, Frank and Mietzner, Thomas and McNamara, Case and Thater, Frank and Freymond, Céline and Jaruwat, Aritsara and Pinthong, Chatchadaporn and Riangrungroj, Pinpunya and Oufir, Mouhssin and Hamburger, Matthias and Mäser, Pascal and Sanz-Alonso, Laura M. and Charman, Susan and Wittlin, Sergio and Yuthavong, Yongyuth and Chaiyen, Pimchai and Diederich, François. (2015) Inhibitors of plasmodial serine hydroxymethyltransferase (SHMT) : co-crystal structures of pyrazolopyrans with potent blood-and liver-stage activities. Journal of Medicinal Chemistry, 58 (7). pp. 3117-3130.

Bürstner, Nathalie and Roggo, Silvio and Ostermann, Nils and Blank, Jutta and Delmas, Cecile and Freuler, Felix and Gerhartz, Bernd and Hinniger, Alexandra and Hoepfner, Dominic and Liechty, Brigitta and Mihalic, Manuel and Murphy, Jason and Pistorius, Dominik and Rottmann, Matthias and Thomas, Jason R. and Schirle, Markus and Schmitt, Esther K.. (2015) Gift from nature : cyclomarin s kills Mycobacteria and malaria parasites by distinct modes of action. ChemBioChem, 16 (17). pp. 2433-2436.

2014

Urbán, Patricia and Valle-Delgado, Juan José and Mauro, Nicolò and Marques, Joana and Manfredi, Amedea and Rottmann, Matthias and Ranucci, Elisabetta and Ferruti, Paolo and Fernàndez-Busquets, Xavier. (2014) Use of poly(amidoamine) drug conjugates for the delivery of antimalarials to Plasmodium. Journal of controlled release : official journal of the Controlled Release Society, Vol. 177. pp. 84-95.

Kunfermann, Andrea and Witschel, Matthias and Illarionov, Boris and Martin, René and Rottmann, Matthias and Höffken, H. Wolfgang and Seet, Michael and Eisenreich, Wolfgang and Knölker, Hans-Joachim and Fischer, Markus and Bacher, Adelbert and Groll, Michael and Diederich, François. (2014) Pseudilins : halogenated, allosteric inhibitors of the non-mevalonate pathway enzyme IspD. Angewandte Chemie. International edition in English, Vol. 53, H. 8. pp. 2235-2239.

Brancucci, Nicolas M. B. and Bertschi, Nicole L. and Zhu, Lei and Niederwieser, Igor and Chin, Wai Hoe and Wampfler, Rahel and Freymond, Céline and Rottmann, Matthias and Felger, Ingrid and Bozdech, Zbynek and Voss, Till S.. (2014) Heterochromatin protein 1 secures survival and transmission of malaria parasites. Cell host & microbe, Vol. 16, H. 2. pp. 165-176.

Kuhen, Kelli L. and Chatterjee, Arnab K. and Rottmann, Matthias and Gagaring, Kerstin and Borboa, Rachel and Buenviaje, Jennifer and Chen, Zhong and Francek, Carolyn and Wu, Tao and Nagle, Advait and Barnes, S. Whitney and Plouffe, David and Lee, Marcus C. S. and Fidock, David A. and Graumans, Wouter and van de Vegte-Bolmer, Marga and van Gemert, Geert J. and Wirjanata, Grennady and Sebayang, Boni and Marfurt, Jutta and Russell, Bruce and Suwanarusk, Rossarin and Price, Ric N. and Nosten, Francois and Tungtaeng, Anchalee and Gettayacamin, Montip and Sattabongkot, Jetsumon and Taylor, Jennifer and Walker, John R. and Tully, David and Patra, Kailash P. and Flannery, Erika L. and Vinetz, Joseph M. and Renia, Laurent and Sauerwein, Robert W. and Winzeler, Elizabeth A. and Glynne, Richard J. and Diagana, Thierry T.. (2014) KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrobial agents and chemotherapy, Vol. 58, H. 9. pp. 5060-5067.

Reker, Daniel and Seet, Michael and Pillong, Max and Koch, Christian P. and Schneider, Petra and Witschel, Matthias C. and Rottmann, Matthias and Freymond, Céline and Brun, Reto and Schweizer, Bernd and Illarionov, Boris and Bacher, Adelbert and Fischer, Markus and Diederich, François and Schneider, Gisbert. (2014) Deorphaning pyrrolopyrazines as potent multi-target antimalarial agents. Angewandte Chemie, Jg. 53, Nr. 27. pp. 7079-7084.

2013

Aureggi, V. and Ehmke, V. and Wieland, J. and Schweizer, W. B. and Bernet, B. and Bur, D. and Meyer, S. and Rottmann, M. and Freymond, C. and Brun, R. and Breit, B. and Diederich, F.. (2013) Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes. Chemistry : a European journal, Vol. 19, H. 1. pp. 155-164.

Kemp, Louise E. and Rusch, Marion and Adibekian, Alexander and Bullen, Hayley E. and Graindorge, Arnault and Freymond, Céline and Rottmann, Matthias and Braun-Breton, Catherine and Baumeister, Stefan and Porfetye, Arthur T. and Vetter, Ingrid R. and Hedberg, Christian and Soldati-Favre, Dominique. (2013) Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in toxoplasma gondii. Journal of biological chemistry, Vol. 288, H. 38. pp. 27002-27018.

McNamara, Case W. and Lee, Marcus C. S. and Lim, Chek Shik and Lim, Siau Hoi and Roland, Jason and Nagle, Advait and Simon, Oliver and Yeung, Bryan K. S. and Chatterjee, Arnab K. and McCormack, Susan L. and Manary, Micah J. and Zeeman, Anne-Marie and Dechering, Koen J. and Kumar, T. R. Santha and Henrich, Philipp P. and Gagaring, Kerstin and Ibanez, Maureen and Kato, Nobutaka and Kuhen, Kelli L. and Fischli, Christoph and Rottmann, Matthias and Plouffe, David M. and Bursulaya, Badry and Meister, Stephan and Rameh, Lucia and Trappe, Joerg and Haasen, Dorothea and Timmerman, Martijn and Sauerwein, Robert W. and Suwanarusk, Rossarin and Russell, Bruce and Renia, Laurent and Nosten, Francois and Tully, David C. and Kocken, Clemens H. M. and Glynne, Richard J. and Bodenreider, Christophe and Fidock, David A. and Diagana, Thierry T. and Winzeler, Elizabeth A.. (2013) Targeting Plasmodium PI(4)K to eliminate malaria. Nature, Vol. 504, H. 7479. pp. 248-253.

Ehmke, Veronika and Winkler, Edwin and Banner, David W. and Haap, Wolfgang and Schweizer, W. Bernd and Rottmann, Matthias and Kaiser, Marcel and Freymond, Céline and Schirmeister, Tanja and Diederich, François. (2013) Optimization of triazine nitriles as rhodesain inhibitors : structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L. ChemMedChem : chemistry enabling drug discovery, Vol. 8, H. 6. pp. 967-975.

2012

Mugasa, J. and Qi, W. and Rusch, S. and Rottmann, M. and Beck, H. P.. (2012) Genetic diversity of expressed Plasmodium falciparum var genes from Tanzanian children with severe malaria. Malaria journal, Vol. 11 , 230.

Witschel, M. and Rottmann, M. and Kaiser, M. and Brun, R.. (2012) Agrochemicals against malaria, sleeping sickness, leishmaniasis and Chagas disease. PLoS neglected tropical diseases, Vol. 6, H. 10 , e1805.

Nagle, A. and Wu, T. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Liu, B. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Chuan, T. and Alper, P. B. and Fischli, C. and Brun, R. and Lakshminarayana, S. B. and Rottmann, M. and Diagana, T. T. and Winzeler, E. A. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2012) Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of medicinal chemistry, 55 (9). pp. 4244-4273.

Ehmke, V. and Quinsaat, J. E. and Rivera-Fuentes, P. and Heindl, C. and Freymond, C. and Rottmann, M. and Brun, R. and Schirmeister, T. and Diederich, F.. (2012) Tuning and predicting biological affinity : aryl nitriles as cysteine protease inhibitors. Organic & biomolecular chemistry, Vol. 10, H. 30. pp. 5764-5768.

Mombelli, P. and Witschel, M. C. and van Zijl, A. W. and Geist, J. G. and Rottmann, M. and Freymond, C. and Röhl, F. and Kaiser, M. and Illarionova, V. and Fischer, M. and Siepe, I. and Schweizer, W. B. and Brun, R. and Diederich, F.. (2012) Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates. ChemMedChem, Vol. 7, H. 1. pp. 151-158.

Mäser, P. and Wittlin, S. and Rottmann, M. and Wenzler, T. and Kaiser, M. and Brun, R.. (2012) Antiparasitic agents : new drugs on the horizon. Current opinion in pharmacology, Vol. 12, H. 5. pp. 562-566.

van Pelt-Koops, J. C. and Pett, H. E. and Graumans, W. and Vegte-Bolmer, Mv and van Gemert, G. J. and Rottmann, M. and Yeung, B. K. and Diagana, T. T. and Sauerwein, R. W.. (2012) The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrobial agents and chemotherapy, Vol. 56, H. 7. pp. 3544-3548.

Gemma, S. and Camodeca, C. and Sanna, Coccone and Joshi, B. P. and Bernetti, M. and Moretti, V. and Brogi, S. and Bonache, M. C. and Savini, L. and Taramelli, D. and Basilico, N. and Parapini, S. and Rottmann, M. and Brun, R. and Lamponi, S. and Caccia, S. and Guiso, G. and Summer, R. and Martin, R. and Saponara, S. and Gorelli, B. and Novellino, E. and Campiani, G. and Butini, S.. (2012) Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials : further structure-activity relationships, in vivo studies, and preliminary toxicity profiling. Journal of medicinal chemistry, 55 (15). pp. 6948-6967.

2011

Chadwick, J. and Amewu, R. K. and Marti, F. and Bousejra-El Garah F., and Sharma, R. and Berry, N. G. and Stocks, P. A. and Burrell-Saward H., and Wittlin, S. and Rottmann, M. and Brun, R. and Taramelli, D. and Parapini, S. and Ward, S. A. and O'Neill P. M., . (2011) Antimalarial mannoxanes : hybrid antimalarial drugs with outstanding oral activity profiles and a potential dual mechanism of action. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 8. pp. 1357-1361.

Wu, T. and Nagle, A. and Kuhen, K. and Gagaring, K. and Borboa, R. and Francek, C. and Chen, Z. and Plouffe, D. and Goh, A. and Lakshminarayana, S. B. and Wu, J. and Ang, H. Q. and Zeng, P. and Kang, M. L. and Tan, W. and Tan, M. and Ye, N. and Lin, X. and Caldwell, C. and Ek, J. and Skolnik, S. and Liu, F. and Wang, J. and Chang, J. and Li, C. and Hollenbeck, T. and Tuntland, T. and Isbell, J. and Fischli, C. and Brun, R. and Rottmann, M. and Dartois, V. and Keller, T. and Diagana, T. and Winzeler, E. and Glynne, R. and Tully, D. C. and Chatterjee, A. K.. (2011) Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of medicinal chemistry, 54 (14). pp. 5116-5130.

Schiaffo, C. E. and Rottmann, M. and Wittlin, S. and Dussault, P. H.. (2011) 3-alkoxy-1,2-dioxolanes : synthesis and evaluation as potential antimalarial agents. ACS medicinal chemistry letters, Vol. 2, H. 4. pp. 316-319.

Ehmke, V. and Heindl, C. and Rottmann, M. and Freymond, C. and Schweizer, W. B. and Brun, R. and Stich, A. and Schirmeister, T. and Diederich, F.. (2011) Potent and selective inhibition of cysteine proteases from Plasmodium falciparum and Trypanosoma brucei. ChemMedChem : chemistry enabling drug discovery, Vol. 6, H. 2. pp. 273-278.

Tripathi, A. and Puddick, J. and Prinsep, M. R. and Rottmann, M. and Chan, K. P. and Chen, D. Y. and Tan, L. T.. (2011) Lagunamide C, a cytotoxic cyclodepsipeptide from the marine cyanobacterium Lyngbya majuscula. Phytochemistry : an international journal of plant biochemistry, Vol. 72, H. 18. pp. 2369-2375.

Meister, S. and Plouffe, D. M. and Kuhen, K. L. and Bonamy, G. M. and Wu, T. and Barnes, S. W. and Bopp, S. E. and Borboa, R. and Bright, A. T. and Che, J. and Cohen, S. and Dharia, N. V. and Gagaring, K. and Gettayacamin, M. and Gordon, P. and Groessl, T. and Kato, N. and Lee, M. C. and McNamara, C. W. and Fidock, D. A. and Nagle, A. and Nam, T. G. and Richmond, W. and Roland, J. and Rottmann, M. and Zhou, B. and Froissard, P. and Glynne, R. J. and Mazier, D. and Sattabongkot, J. and Schultz, P. G. and Tuntland, T. and Walker, J. R. and Zhou, Y. and Chatterjee, A. and Diagana, T. T. and Winzeler, E. A.. (2011) Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science, Vol. 334, H. 6061. pp. 1372-1377.

2010

Tripathi, A. and Puddick, J. and Prinsep, M. R. and Rottmann, M. and Tan, L. T.. (2010) Lagunamides A and B : cytotoxic and antimalarial cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula. Journal of natural products, Vol. 73, H. 11. pp. 1810-1814.