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Although abundant in tumor tissue, mast cells have no effect on immunological micro-milieu or growth of HPV-induced or transplanted tumors

Ghouse, Shanawaz Mohammed and Polikarpova, Anastasia and Muhandes, Lina and Dudeck, Jan and Tantcheva-Poór, Iliana and Hartmann, Karin and Lesche, Matthias and Dahl, Andreas and Eming, Sabine and Müller, Werner and Behrendt, Rayk and Roers, Axel. (2018) Although abundant in tumor tissue, mast cells have no effect on immunological micro-milieu or growth of HPV-induced or transplanted tumors. Cell Reports, 22 (1). pp. 27-35.

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Official URL: https://edoc.unibas.ch/70746/

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Abstract

High numbers of mast cells populate the stroma of many types of neoplasms, including human papilloma virus-induced benign and malignant tumors in man and mouse. Equipped with numerous pattern recognition receptors and capable of executing important pro-inflammatory responses, mast cells are considered innate sentinels that significantly impact tumor biology. Mast cells were reported to promote human papilloma virus (HPV)-induced epithelial hyperproliferation and neo-angiogenesis in an HPV-driven mouse model of skin cancer. We analyzed HPV-induced epithelial hyperplasia and squamous cell carcinoma formation, as well as growth of tumors inoculated into the dermis, in mice lacking skin mast cells. Unexpectedly, the absence of mast cells had no effect on HPV-induced epithelial growth or angiogenesis, on growth kinetics of inoculated tumors, or on the immunological tumor micro-milieu. Thus, the conspicuous recruitment of mast cells into tumor tissues cannot necessarily be equated with important mast cell functions in tumor growth.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann)
UniBasel Contributors:Hartmann, Karin
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:2211-1247
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:09 Apr 2020 15:09
Deposited On:09 Apr 2020 15:09

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