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Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations

European Network of National Networks studying Gene-Environment , and van Os, Jim and Rutten, Bart P. and Myin-Germeys, Inez and Delespaul, Philippe and Viechtbauer, Wolfgang and van Zelst, Catherine and Bruggeman, Richard and Reininghaus, Ulrich and Morgan, Craig and Murray, Robin M. and Di Forti, Marta and McGuire, Philip and Valmaggia, Lucia R. and Kempton, Matthew J. and Gayer-Anderson, Charlotte and Hubbard, Kathryn and Beards, Stephanie and Stilo, Simona A. and Onyejiaka, Adanna and Bourque, Francois and Modinos, Gemma and Tognin, Stefania and Calem, Maria and O'Donovan, Michael C. and Owen, Michael J. and Holmans, Peter and Williams, Nigel and Craddock, Nicholas and Richards, Alexander and Humphreys, Isla and Meyer-Lindenberg, Andreas and Leweke, F. Markus and Tost, Heike and Akdeniz, Ceren and Rohleder, Cathrin and Bumb, J. Malte and Schwarz, Emanuel and Alptekin, Köksal and Üçok, Alp and Saka, Meram Can and Atbaşoğlu, E. Cem and Gülöksüz, Sinan and Gumus-Akay, Guvem and Cihan, Burçin and Karadağ, Hasan and Soygür, Haldan and Cankurtaran, Eylem Şahin and Ulusoy, Semra and Akdede, Berna and Binbay, Tolga and Ayer, Ahmet and Noyan, Handan and Karadayı, Gülşah and Akturan, Elçin and Ulaş, Halis and Arango, Celso and Parellada, Mara and Bernardo, Miguel and Sanjuán, Julio and Bobes, Julio and Arrojo, Manuel and Santos, Jose Luis and Cuadrado, Pedro and Rodríguez Solano, José Juan and Carracedo, Angel and García Bernardo, Enrique and Roldán, Laura and López, Gonzalo and Cabrera, Bibiana and Cruz, Sabrina and Díaz Mesa, Eva Ma and Pouso, María and Jiménez, Estela and Sánchez, Teresa and Rapado, Marta and González, Emiliano and Martínez, Covadonga and Sánchez, Emilio and Olmeda, Ma Soledad and de Haan, Lieuwe and Velthorst, Eva and van der Gaag, Mark and Selten, Jean-Paul and van Dam, Daniella and van der Ven, Elsje and van der Meer, Floor and Messchaert, Elles and Kraan, Tamar and Burger, Nadine and Leboyer, Marion and Szoke, Andrei and Schürhoff, Franck and Llorca, Pierre-Michel and Jamain, Stéphane and Tortelli, Andrea and Frijda, Flora and Vilain, Jeanne and Galliot, Anne-Marie and Baudin, Grégoire and Ferchiou, Aziz and Richard, Jean-Romain and Bulzacka, Ewa and Charpeaud, Thomas and Tronche, Anne-Marie and De Hert, Marc and van Winkel, Ruud and Decoster, Jeroen and Derom, Catherine and Thiery, Evert and Stefanis, Nikos C. and Sachs, Gabriele and Aschauer, Harald and Lasser, Iris and Winklbaur, Bernadette and Schlögelhofer, Monika and Riecher-Rössler, Anita and Borgwardt, Stefan and Walter, Anna and Harrisberger, Fabienne and Smieskova, Renata and Rapp, Charlotte and Ittig, Sarah and Soguel-dit-Piquard, Fabienne and Studerus, Erich and Klosterkötter, Joachim and Ruhrmann, Stephan and Paruch, Julia and Julkowski, Dominika and Hilboll, Desiree and Sham, Pak C. and Cherny, Stacey S. and Chen, Eric Y. H. and Campbell, Desmond D. and Li, Miaoxin and Romeo-Casabona, Carlos María and Emaldi Cirión, Aitziber and Urruela Mora, Asier and Jones, Peter and Kirkbride, James and Cannon, Mary and Rujescu, Dan and Tarricone, Ilaria and Berardi, Domenico and Bonora, Elena and Seri, Marco and Marcacci, Thomas and Chiri, Luigi and Chierzi, Federico and Storbini, Viviana and Braca, Mauro and Minenna, Maria Gabriella and Donegani, Ivonne and Fioritti, Angelo and La Barbera, Daniele and La Cascia, Caterina Erika and Mulè, Alice and Sideli, Lucia and Sartorio, Rachele and Ferraro, Laura and Tripoli, Giada and Seminerio, Fabio and Marinaro, Anna Maria and McGorry, Patrick and Nelson, Barnaby and Amminger, G. Paul and Pantelis, Christos and Menezes, Paulo R. and Del-Ben, Cristina M. and Gallo Tenan, Silvia H. and Shuhama, Rosana and Ruggeri, Mirella and Tosato, Sarah and Lasalvia, Antonio and Bonetto, Chiara and Ira, Elisa and Nordentoft, Merete and Krebs, Marie-Odile and Barrantes-Vidal, Neus and Cristóbal, Paula and Kwapil, Thomas R. and Brietzke, Elisa and Bressan, Rodrigo A. and Gadelha, Ary and Maric, Nadja P. and Andric, Sanja and Mihaljevic, Marina and Mirjanic, Tijana. (2014) Identifying gene-environment interactions in schizophrenia: contemporary challenges for integrated, large-scale investigations. Schizophrenia Bulletin, 40 (4). pp. 729-736.

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Official URL: https://edoc.unibas.ch/70612/

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Abstract

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype.
Faculties and Departments:03 Faculty of Medicine
03 Faculty of Medicine > Bereich Psychiatrie (Klinik)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Riecher-Rössler)
UniBasel Contributors:Studerus, Erich
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Oxford University Press
ISSN:0586-7614
e-ISSN:1745-1701
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:31 May 2020 20:13
Deposited On:31 May 2020 20:13

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