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Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets

Lang, Elisabeth and Mallien, Anne S. and Vasilescu, Andrei-Nicolae and Hefter, Dimitri and Luoni, Alessia and Riva, Marco A. and Borgwardt, Stefan and Sprengel, Rolf and Lang, Undine E. and Gass, Peter and Inta, Dragos. (2018) Molecular and cellular dissection of NMDA receptor subtypes as antidepressant targets. Neuroscience and biobehavioral reviews, 84. pp. 352-358.

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Official URL: https://edoc.unibas.ch/65564/

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Abstract

A growing body of evidence supports the idea that drugs targeting the glutamate system may represent a valuable therapeutic alternative in major depressive disorders (MDD). The rapid and prolonged mood elevating effect of the NMDA receptor (NMDAR) antagonist ketamine has been studied intensely. However, its clinical use is hampered by deleterious side-effects, such as psychosis. Therefore, a better understanding of the mechanisms of the psychotropic effects after NMDAR blockade is necessary to develop glutamatergic antidepressants with improved therapeutic profile. Here we review recent experimental data that addressed molecular/cellular determinants of the antidepressant effect mediated by inactivating NMDAR subtypes. We refer to results obtained both in pharmacological and genetic animal models, ranging from global to conditional NMDAR manipulation. Our main focus is on the contribution of different NMDAR subtypes to the psychoactive effects induced by NMDAR ablation/blockade. We review data analyzing the effect of NMDAR subtype deletions limited to specific neuronal populations/brain areas in the regulation of mood. Altogether, these studies suggest effective and putative specific NMDAR drug targets for MDD treatment.
Faculties and Departments:03 Faculty of Medicine
03 Faculty of Medicine > Bereich Psychiatrie (Klinik)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik)
03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Erwachsenenpsychiatrie (Lang)
03 Faculty of Medicine > Departement Klinische Forschung
UniBasel Contributors:Lang, Undine
Item Type:Article, refereed
Article Subtype:Research Article
ISSN:1873-7528
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:26 Apr 2020 19:47
Deposited On:26 Apr 2020 19:47

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