Cortada, Maurizio and Levano, Soledad and Hall, Michael N. and Bodmer, Daniel. (2023) mTORC2 regulates auditory hair cell structure and function. iScience, 26 (9). p. 107687.
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Official URL: https://edoc.unibas.ch/95878/
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Abstract
mTOR broadly controls cell growth, but little is known about the role of mTOR complex 2 (mTORC2) in the inner ear. To investigate the role of mTORC2 in sensory hair cells (HCs), we generated HC-specific; Rictor; knockout (HC-RicKO) mice. HC-RicKO mice exhibited early-onset, progressive, and profound hearing loss. Increased DPOAE thresholds indicated outer HC dysfunction. HCs are lost, but this occurs after hearing loss. Ultrastructural analysis revealed stunted and absent stereocilia in outer HCs. In inner HCs, the number of synapses was significantly decreased and the remaining synapses displayed a disrupted actin cytoskeleton and disorganized Ca; 2+; channels. Thus, the mTORC2 signaling pathway plays an important role in regulating auditory HC structure and function via regulation of the actin cytoskeleton. These results provide molecular insights on a central regulator of cochlear HCs and thus hearing.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Hall) |
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UniBasel Contributors: | Hall, Michael N. |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Elsevier |
e-ISSN: | 2589-0042 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 16 Oct 2023 12:43 |
Deposited On: | 16 Oct 2023 12:42 |
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