Protein target highlights in CASP15: Analysis of models by structure providers

Alexander, Leila T. and Durairaj, Janani and Kryshtafovych, Andriy and Abriata, Luciano A. and Bayo, Yusupha and Bhabha, Gira and Breyton, Cécile and Caulton, Simon G. and Chen, James and Degroux, Séraphine and Ekiert, Damian C. and Erlandsen, Benedikte S. and Freddolino, Peter L. and Gilzer, Dominic and Greening, Chris and Grimes, Jonathan M. and Grinter, Rhys and Gurusaran, Manickam and Hartmann, Marcus D. and Hitchman, Charlie J. and Keown, Jeremy R. and Kropp, Ashleigh and Kursula, Petri and Lovering, Andrew L. and Lemaitre, Bruno and Lia, Andrea and Liu, Shiheng and Logotheti, Maria and Lu, Shuze and Markússon, Sigurbjörn and Miller, Mitchell D. and Minasov, George and Niemann, Hartmut H. and Opazo, Felipe and Phillips, George N. and Davies, Owen R. and Rommelaere, Samuel and Rosas-Lemus, Monica and Roversi, Pietro and Satchell, Karla and Smith, Nathan and Wilson, Mark A. and Wu, Kuan-Lin and Xia, Xian and Xiao, Han and Zhang, Wenhua and Zhou, Z. Hong and Fidelis, Krzysztof and Topf, Maya and Moult, John and Schwede, Torsten. (2023) Protein target highlights in CASP15: Analysis of models by structure providers. Proteins: Structure, Function, and Bioinformatics . Online ahead of print..

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Official URL: https://edoc.unibas.ch/95444/

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Abstract

We present an in-depth analysis of selected CASP15 targets, focusing on their biological and functional significance. The authors of the structures identify and discuss key protein features and evaluate how effectively these aspects were captured in the submitted predictions. While the overall ability to predict three-dimensional protein structures continues to impress, reproducing uncommon features not previously observed in experimental structures is still a challenge. Furthermore, instances with conformational flexibility and large multimeric complexes highlight the need for novel scoring strategies to better emphasize biologically relevant structural regions. Looking ahead, closer integration of computational and experimental techniques will play a key role in determining the next challenges to be unraveled in the field of structural molecular biology.

Faculties and Departments:	05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede)
UniBasel Contributors:	Schwede, Torsten and Alexander, Leila and Durairaj, Janani
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	Wiley-Blackwell
ISSN:	0887-3585
e-ISSN:	1097-0134
Note:	Publication type according to Uni Basel Research Database: Journal article
Language:	English
Identification Number:	doi: 10.1002/prot.26545 pmid: 37493353
edoc DOI:	10.5451/unibas-ep95444
Last Modified:	12 Dec 2023 09:48
Deposited On:	11 Dec 2023 10:44

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