The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease

Savaskan, Egemen and Jockers, Ralf and Ayoub, Mohammed and Angeloni, Debora and Fraschini, Franco and Flammer, Josef and Eckert, Anne and Müller-Spahn, Franz and Meyer, Peter. (2007) The MT2 melatonin receptor subtype is present in human retina and decreases in Alzheimer's disease. Current Alzheimer research, Vol. 4, No. 1. pp. 47-51.

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Official URL: http://edoc.unibas.ch/dok/A5253454

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The pineal and retinal melatonin regulates endogenous circadian rhythms, and has various physiological functions including neuromodulatory and vasoactive actions, antioxidative and neuroprotective properties. We have previously demonstrated that the melatonin 1a-receptor (MT(1)) is localized in human retinal cells and that the expression of MT(1) is increased in Alzheimer's disease (AD) patients. We now present the first immunohistochemical evidence for the cellular distribution of the second melatonin receptor, MT(2), in the human retina and in AD patients. In elderly controls, MT(2) was localized to ganglion and bipolar cells in the inner nuclear layer, and to the inner segments of the photoreceptor cells. In addition, cellular processes in inner and outer plexiform layers were strongly positive for MT(2). In AD patients the overall intensity of MT(2)-staining was distinctly decreased in all observed cellular localizations. Our results indicate that MT(2) in the humans, similar to MT(1), may indeed be involved in transmitting melatonin's effects in the retina, and AD pathology may impair MT(2) expression. Since our previous results showed an increase in MT(1) expression in AD retina, the two melatonin receptor subtypes appear to be differentially affected by the course of the neurodegenerative disorder.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK
UniBasel Contributors:Eckert, Anne
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Bentham Science Publishers
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:26
Deposited On:22 Mar 2012 13:49

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