Prepoudis, Alexandra and Koechlin, Luca and Nestelberger, Thomas and Boeddinghaus, Jasper and Lopez-Ayala, Pedro and Wussler, Desiree and Zimmermann, Tobias and Rubini Giménez, Maria and Strebel, Ivo and Puelacher, Christian and Shrestha, Samyut and Keller, Dagmar I. and Christ, Michael and Gualandro, Danielle M. and Twerenbold, Raphael and Martinez-Nadal, Gemma and Lopez-Barbeito, Beatriz and Miro, Oscar and Mueller, Christian and Apace investigators, .
(2022)
Incidence, clinical presentation, management, and outcome of acute pericarditis and myopericarditis.
European Heart Journal – Acute CardioVascular Care, 11 (2).
pp. 137-147.
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Abstract
Little is known about the epidemiology, clinical presentation, management, and outcome of acute pericarditis and myopericarditis.; The final diagnoses of acute pericarditis, myopericarditis, and non-ST-segment elevation myocardial infarction (NSTEMI) of patients presenting to seven emergency departments in Switzerland with acute chest pain were centrally adjudicated by two independent cardiologists using all information including serial measurements of high-sensitivity cardiac troponin T. The overall incidence of pericarditis and myopericarditis was estimated relative to the established incidence of NSTEMI. Current management and long-term outcome of both conditions were also assessed. Among 2533 chest pain patients, the incidence of pericarditis, myopericarditis, and NSTEMI were 1.9% (n = 48), 1.1% (n = 29), and 21.6% (n = 548), respectively. Accordingly, the estimated incidence of pericarditis and myopericarditis in Switzerland was 10.1 [95% confidence interval (95% CI) 9.3-10.9] and 6.1 (95% CI 5.6-6.7) cases per 100 000 population per year, respectively, vs. 115.0 (95% CI 112.3-117.6) cases per 100 000 population per year for NSTEMI. Pericarditis (85% male, median age 46 years) and myopericarditis (62% male, median age 56 years) had male predominance, and commonly (50% and 97%, respectively) resulted in hospitalization. No patient with pericarditis or myopericarditis died or had life-threatening arrhythmias within 30 days [incidence 0% (95% CI 0.0-4.8%)]. Compared with NSTEMI, the 2-year all-cause mortality adjusted hazard ratio of pericarditis and myopericarditis was 0.40 (95% CI 0.05-2.96), being 0.59 (95% CI 0.40-0.88) for non-cardiac causes of chest pain.; Pericarditis and myopericarditis are substantially less common than NSTEMI and have an excellent short- and long-term outcome.; ClinicalTrial.gov, number NCT00470587, https://clinicaltrials.gov/ct2/show/NCT00470587.
Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Kardiologie > Klinische Outcomeforschung Kardiologie (Müller) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Kardiologie > Klinische Outcomeforschung Kardiologie (Müller) 03 Faculty of Medicine > Departement Klinische Forschung |
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UniBasel Contributors: | Prepoudis, Alexandra and Koechlin, Luca and Nestelberger, Thomas and Boeddinghaus, Jasper and Lopez Ayala, Pedro and Wussler, Desiree and Zimmermann, Tobias and Rubini Giménez, Maria and Strebel, Ivo and Puelacher, Christian and Shrestha, Samyut and Mueller, Christian |
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Item Type: | Article, refereed |
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Article Subtype: | Research Article |
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Publisher: | Oxford University Press |
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ISSN: | 2048-8726 |
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e-ISSN: | 2048-8734 |
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Note: | Publication type according to Uni Basel Research Database: Journal article |
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Language: | English |
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Identification Number: | |
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edoc DOI: | |
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Last Modified: | 26 Jun 2023 08:35 |
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Deposited On: | 26 Jun 2023 08:35 |
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