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Geminin regulates multiple steps of the chromosome inheritance cycle

Tachibana, Kiku-e K. and Nigg, Erich A.. (2006) Geminin regulates multiple steps of the chromosome inheritance cycle. Cell cycle, Vol. 5, no. 2. pp. 151-154.

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Official URL: http://edoc.unibas.ch/dok/A5249359

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Abstract

Centrosome duplication like DNA replication must occur exactly once per cell cycle to maintain genomic stability. Cell fusion and microinjection assays gave rise to the concept of "licensing" and uncovered nuclear-intrinsic blocks to genomic overreplication and recently also centrosome-intrinsic blocks to overduplication. The chromatin licence has been defined in molecular terms as the pre-replication complex (preRC) antagonised by its regulator geminin. Geminin prevents preRC assembly and overreplication in S and G(2) phases. However, the mechanisms that limit centrosome duplication including a potential centrosome licence remain poorly understood. Here, we discuss our recent data demonstrating that loss of the licensing inhibitor geminin causes centrosome overduplication in addition to genomic overreplication. We present further evidence that geminin is an inhibitor of centrosome duplication. Therefore, geminin is involved in regulating multiple steps of the chromosome inheritance cycle, including DNA replication, centrosome duplication and chromosome segregation.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum
05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Cell Biology (Nigg)
UniBasel Contributors:Nigg, Erich A.
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Landes Bioscience
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:04 Sep 2015 14:31
Deposited On:22 Mar 2012 13:49

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