Loiseau, C. and Brites, D. and Reinhard, M. and Zurcher, K. and Borrell, S. and Ballif, M. and Fenner, L. and Cox, H. and Rutaihwa, L. K. and Wilkinson, R. J. and Yotebieng, M. and Carter, E. J. and Abimiku, A. and Marcy, O. and Gotuzzo, E. and Avihingsanon, A. and Zetola, N. and Doulla, B. and Bottger, E. C. and Egger, M. and Gagneux, S.. (2020) HIV coinfection is associated with low fitness rpoB variants in rifampicin-resistant Mycobacterium tuberculosis. Antimicrobial agents and chemotherapy, 64 (10). e00782-20.
![[img]](https://edoc.unibas.ch/style/images/fileicons/application_pdf.png) |
PDF
- Published Version
Available under License CC BY (Attribution). 1149Kb |
Official URL: https://edoc.unibas.ch/91186/
Downloads: Statistics Overview
Abstract
We analysed 312 drug-resistant genomes of Mycobacterium tuberculosis (Mtb) collected from HIV coinfected and HIV negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant Mtb strains isolated from HIV coinfected patients carried disproportionally more resistance-conferring mutations in rpoB that are associated with a low fitness in the absence of the drug, suggesting these low fitness rpoB variants can thrive in the context of reduced host immunity.
| Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Ecology and Evolution Unit (Gagneux) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Diagnostic (Nickel) |
|---|---|
| UniBasel Contributors: | Loiseau, Chloé Marie and Brites, Daniela and Reinhard, Miriam and Borrell Farnov, Sonia and Rutaihwa, Liliana and Gagneux, Sebastien |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| ISSN: | 0066-4804 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Related URLs: | |
| Identification Number: |
|
| edoc DOI: | |
| Last Modified: | 28 Dec 2022 13:31 |
| Deposited On: | 28 Dec 2022 13:31 |
Repository Staff Only: item control page