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Weight change and cognitive performance

Brubacher, D. and Monsch, A. U. and Stähelin, H. B.. (2004) Weight change and cognitive performance. International journal of obesity and related metabolic disorders, Vol. 28, H. 9. pp. 1163-1167.

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Official URL: http://edoc.unibas.ch/dok/A5250790

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Abstract

OBJECTIVE: To investigate whether under- or overweight and weight change is associated with cognitive performance of elderly citizens. DESIGN: Explorative analysis out of the Basel Study cohort. SUBJECTS: In all, 531 healthy subjects (445 men/86 women) were assessed with the Consortium to Establish a Registry for Alzheimer's Disease-Neuropsychological Assessment Battery (CERAD-NAB) in 2000 (age: 69.4+/-7.8 y) and weight measurements obtained in 1990 (body mass index (BMI): 25.2+/-3.1 kg/m(2)) and in 2000 (BMI: 25.6+/-3.4 kg/m(2)). METHODS: The predictive power of the annual change in BMI with cognitive performance was investigated by a binary logistic regression analysis (backward) using sex, age, BMI 1990, BMI 2000, diastolic blood pressure, diabetes status, and optimal health status as additional predictors. RESULTS: In the last step, the following variables remained in the model: annual change in BMI (quadratic term; P>0.01); ApoE genotype (P>0.05); and optimal health status (P>0.01). CONCLUSION: The association between the extent of weight change and poorer cognitive performance could be either a consequence of cognitive impairment or an early symptom of neurodegenerative decline.
Faculties and Departments:03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Geriatrie
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Geriatrie
07 Faculty of Psychology > Departement Psychologie
UniBasel Contributors:Monsch, Andreas U
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Macmillan
ISSN:0307-0565
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:25
Deposited On:22 Mar 2012 13:47

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