Kusejko, K. and Tschumi, N. and Chaudron, S. E. and Nguyen, H. and Battegay, M. and Bernasconi, E. and Boni, J. and Huber, M. and Calmy, A. and Cavassini, M. and Egle, A. and Grabmeier-Pfistershammer, K. and Haas, B. and Hirsch, H. and Klimkait, T. and Öllinger, A. and Perreau, M. and Ramette, A. and Babouee Flury, B. and Sarcletti, M. and Scherrer, A. and Schmid, P. and Yerly, S. and Zangerle, R. and Gunthard, H. F. and Kouyos, R. D. and Swiss HIV Cohort Study, and Austrian HIV Cohort Study, .
(2022)
Similar but different: integrated phylogenetic analysis of Austrian and Swiss HIV-1 sequences reveal differences in transmission patterns of the local HIV-1 epidemics.
J Acquir Immune Defic Syndr, 90 (4).
e4-e12.
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Abstract
OBJECTIVES: Phylogenetic analyses of two or more countries allow to detect differences in transmission dynamics of local HIV-1 epidemics beyond differences in demographic characteristics. METHODS: A maximum-likelihood phylogenetic tree was built using pol-sequences of the Swiss HIV Cohort Study (SHCS) and the Austrian HIV Cohort Study (AHIVCOS), with international background sequences. Three types of phylogenetic cherries (clusters of size 2) were analyzed further: 1) Domestic cherries, 2) International cherries and 3) SHCS/AHIVCOS-cherries. Transmission group and ethnicities observed within the cherries were compared to the respective distribution expected from a random distribution of patients on the phylogeny. RESULTS: The demographic characteristics of the AHIVCOS (included patients: 3'141) and the SHCS (included patients: 12'902) are very similar. In the AHIVCOS, 36.5% of the patients were in domestic cherries, 8.3% in international cherries, and 7.0% in SHCS/AHIVCOS cherries. Similarly, in the SHCS, 43.0% of the patients were in domestic cherries, 8.2% in international cherries, and 1.7% in SHCS/AHIVCOS cherries. While international cherries in the SHCS were dominated by heterosexuals (HET) with MSM being underrepresented, the opposite was the case for the AHIVCOS. In both cohorts, cherries with one patient belonging to the transmission group intravenous drug user (IDU) and the other one non-IDU were underrepresented. CONCLUSION: In both cohorts, international HIV transmission plays a major role in the local epidemics, mostly driven by MSM in the AHIVOS, and by HET in the SHCS, highlighting the importance of international collaborations to understand global HIV transmission links on the way to eliminate HIV.
Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medicine (MED) > Clinical Research (Reither) |
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UniBasel Contributors: | Tschumi, Nadine |
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Item Type: | Article, refereed |
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Article Subtype: | Research Article |
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ISSN: | 1944-7884 (Electronic)1525-4135 (Linking) |
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Note: | Publication type according to Uni Basel Research Database: Journal article |
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Language: | English |
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Identification Number: | |
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edoc DOI: | |
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Last Modified: | 27 Dec 2022 11:02 |
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Deposited On: | 27 Dec 2022 11:02 |
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