Pan, Fei and Altenried, Stefanie and Scheibler, Subas and Rodriguez Fernandez, Irene and Giovannini, Giorgia and Ren, Qun. (2022) Ultrafast Determination of Antimicrobial Resistant Staphylococcus aureus Specifically Captured by Functionalized Magnetic Nanoclusters. ACS Sensors, 7 (11). pp. 3491-3500.
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Official URL: https://edoc.unibas.ch/90136/
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Abstract
Sepsis, the systemic response to infection, is a life-threatening situation for patients and leads to high mortality, especially when caused by antimicrobial resistant pathogens. Prompt diagnosis and identification of the pathogenic bacteria, including their antibiotic resistance, are highly desired to yield a timely decision for treatment. Here, we aim to develop a platform for rapid isolation and efficient identification of; Staphylococcus aureus; , the most frequently occurring pathogen in sepsis. A peptide (VPHNPGLISLQG, SA5-1), specifically binding to; S. aureus; , was conjugated to the PEGylated magnetic nanoclusters, successfully enabling the specific capture and enrichment of; S. aureus; from blood serum. Consequently, fast detection of the antimicrobial resistance of the collected; S. aureus; was achieved within 30 min using a novel luminescent probe. These magnetic nanoclusters manifest a promising diagnostic prospect to combat sepsis.
Faculties and Departments: | 05 Faculty of Science 05 Faculty of Science > Departement Chemie |
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UniBasel Contributors: | Pan, Fei |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | American Chemical Society |
e-ISSN: | 2379-3694 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: |
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edoc DOI: | |
Last Modified: | 24 Oct 2023 01:30 |
Deposited On: | 30 Nov 2022 07:48 |
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