Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: the ELAPSE project

Liu, S. and Jørgensen, J. T. and Ljungman, P. and Pershagen, G. and Bellander, T. and Leander, K. and Magnusson, P. K. E. and Rizzuto, D. and Hvidtfeldt, U. A. and Raaschou-Nielsen, O. and Wolf, K. and Hoffman, B. and Brunekreef, B. and Strak, M. and Chen, J. and Mehta, A. and Atkinson, R. W. and Bauwelinck, M. and Varraso, R. and Boutron-Ruault, M. C. and Brandt, J. and Cesaroni, G. and Forastiere, F. and Fecht, D. and Gulliver, J. and Hertel, O. and de Hoogh, K. and Janssen, N. A. H. and Katsouyanni, K. and Ketzel, M. and Klompmaker, J. O. and Nagel, G. and Oftedal, B. and Peters, A. and Tjønneland, A. and Rodopoulou, S. P. and Samoli, E. and Bekkevold, T. and Sigsgaard, T. and Stafoggia, M. and Vienneau, D. and Weinmayr, G. and Hoek, G. and Andersen, Z. J.. (2021) Long-term exposure to low-level air pollution and incidence of chronic obstructive pulmonary disease: the ELAPSE project. Environment international, 146. p. 106267.

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Official URL: https://edoc.unibas.ch/89164/

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Abstract

Background; : Air pollution has been suggested as a risk factor for chronic obstructive pulmonary disease (COPD), but evidence is sparse and inconsistent.; Objectives; : We examined the association between long-term exposure to low-level air pollution and COPD incidence.; Methods; : Within the 'Effects of Low-Level Air Pollution: A Study in Europe' (ELAPSE) study, we pooled data from three cohorts, from Denmark and Sweden, with information on COPD hospital discharge diagnoses. Hybrid land use regression models were used to estimate annual mean concentrations of particulate matter with a diameter < 2.5 μm (PM2.5), nitrogen dioxide (NO2), and black carbon (BC) in 2010 at participants' baseline residential addresses, which were analysed in relation to COPD incidence using Cox proportional hazards models.; Results; : Of 98,058 participants, 4,928 developed COPD during 16.6 years mean follow-up. The adjusted hazard ratios (HRs) and 95% confidence intervals for associations with COPD incidence were 1.17 (1.06, 1.29) per 5 μg/ m3 for PM2.5, 1.11 (1.06, 1.16) per 10 μg/m3 for NO2, and 1.11 (1.06, 1.15) per 0.5 10

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Environmental Exposures and Health Systems Research > Physical Hazards and Health (Röösli)
UniBasel Contributors:	de Hoogh, Kees and Vienneau, Danielle
Item Type:	Article, refereed
Article Subtype:	Research Article
ISSN:	0160-4120
Note:	Publication type according to Uni Basel Research Database: Journal article
Language:	English
Related URLs:	Document
Identification Number:	doi: 10.1016/j.envint.2020.106267 pmid: 33276316
edoc DOI:	10.5451/unibas-ep89164
Last Modified:	20 Dec 2022 12:09
Deposited On:	20 Dec 2022 12:09

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