The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant

López, M. G. and Chiner-Oms, A. and García de Viedma, D. and Ruiz-Rodriguez, P. and Bracho, M. A. and Cancino-Muñoz, I. and D'Auria, G. and de Marco, G. and García-González, N. and Goig, G. A. and Gómez-Navarro, I. and Jiménez-Serrano, S. and Martinez-Priego, L. and Ruiz-Hueso, P. and Ruiz-Roldán, L. and Torres-Puente, M. and Alberola, J. and Albert, E. and Aranzamendi Zaldumbide, M. and Bea-Escudero, M. P. and Boga, J. A. and Bordoy, A. E. and Canut-Blasco, A. and Carvajal, A. and Cilla Eguiluz, G. and Cordón Rodríguez, M. L. and Costa-Alcalde, J. J. and de Toro, M. and de Toro Peinado, I. and Del Pozo, J. L. and Duchêne, S. and Fernández-Pinero, J. and Fuster Escrivá, B. and Gimeno Cardona, C. and González Galán, V. and Gonzalo Jiménez, N. and Hernáez Crespo, S. and Herranz, M. and Lepe, J. A. and López-Causapé, C. and López-Hontangas, J. L. and Martín, V. and Martró, E. and Milagro Beamonte, A. and Montes Ros, M. and Moreno-Muñoz, R. and Navarro, D. and Navarro-Marí, J. M. and Not, A. and Oliver, A. and Palop-Borrás, B. and Parra Grande, M. and Pedrosa-Corral, I. and Pérez González, M. C. and Pérez-Lago, L. and Pérez-Ruiz, M. and Pineiro Vazquez, L. and Rabella, N. and Rezusta, A. and Robles Fonseca, L. and Rodríguez-Villodres, A. and Sanbonmatsu-Gámez, S. and Sicilia, J. and Soriano, A. and Tirado Balaguer, M. D. and Torres, I. and Tristancho, A. and Marimón, J. M. and SeqCovid-Spain Consortium, and Coscolla, M. and González-Candelas, F. and Comas, I.. (2021) The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant. Nat Genet, 53 (10). pp. 1405-1414.

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Official URL: https://edoc.unibas.ch/89158/

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Abstract

The coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re < 1), also reflected in the replacement of SECs by a new variant over the summer of 2020. In summary, we reveal a notable difference in the initial genetic makeup of SARS-CoV-2 in Spain compared with other European countries and show evidence to support the effectiveness of lockdown measures in controlling virus spread, even for the most successful genetic variants.

Faculties and Departments:	09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Medical Parasitology and Infection Biology (MPI) > Tuberculosis Ecology and Evolution Unit (Gagneux)
UniBasel Contributors:	Goig, Galo
Item Type:	Article, refereed
Article Subtype:	Research Article
ISSN:	1546-1718 (Electronic)1061-4036 (Linking)
Note:	Publication type according to Uni Basel Research Database: Journal article
Identification Number:	doi: 10.1038/s41588-021-00936-6 pmid: 34594042
Last Modified:	20 Dec 2022 12:05
Deposited On:	20 Dec 2022 12:05

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