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Decreased fractional anisotropy in the middle cerebellar peduncle in children with epilepsy and / or attention deficit/hyperactivity disorder : a preliminary study

Bechtel, N. and Kobel, M. and Penner, I. K. and Klarhöfer, M. and Scheffler, K. and Opwis, K. and Weber, P.. (2009) Decreased fractional anisotropy in the middle cerebellar peduncle in children with epilepsy and / or attention deficit/hyperactivity disorder : a preliminary study. Epilepsy & behavior, Vol. 15. pp. 294-298.

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Official URL: http://edoc.unibas.ch/dok/A5250623

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Abstract

Children with epilepsy are at increased risk for attention deficit/hyperactivity disorder (ADHD). It has been shown that the cerebellum plays a major role in the pathophysiology of ADHD. We aimed to clarify whether children with combined epilepsy/ADHD have the same neurocerebellar pathophysiology as children with developmental ADHD. Eight boys with combined epilepsy/ADHD, 14 boys with developmental ADHD, and 12 healthy boys were investigated using diffusion tensor imaging generating fractional anisotropy (FA) maps. Healthy controls exhibited more FA in the left and in the right middle cerebellar peduncle compared with children with combined epilepsy/ADHD, and more FA in the right middle cerebellar peduncle compared with children with developmental ADHD. Our data show deficient cerebellar connections in both patient groups and endorse the crucial role of the cerebellum in the pathophysiology of ADHD. Our results suggest that ADHD seen in epilepsy might have the same cerebellar pathology as in developmental ADHD.
Faculties and Departments:03 Faculty of Medicine > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Radiologische Physik (Scheffler)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Querschnittsfächer (Klinik) > Ehemalige Einheiten Querschnittsfächer (Klinik) > Radiologische Physik (Scheffler)
03 Faculty of Medicine > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Neuro- und Entwicklungspädiatrie (Weber)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Kinder- und Jugendheilkunde (Klinik) > Kinder- und Jugendheilkunde (UKBB) > Neuro- und Entwicklungspädiatrie (Weber)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Persönlichkeits- und Entwicklungspsychologie > Allgemeine Psychologie und Methodologie (Opwis)
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Cognitive Research (Penner)
UniBasel Contributors:Opwis, Klaus and Penner, Iris-Katharina and Scheffler, Klaus and Bechtel, Nina and Weber, Peter
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:1525-5050
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:24 May 2013 09:01
Deposited On:22 Mar 2012 13:45

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