edoc

Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk?

Taylor, C. Barr and Conrad, Ansgar and Wilhelm, Frank H. and Strachowski, Diane and Khaylis, Anna and Neri, Eric and Giese-Davis, Janine and Roth, Walton T. and Cooke, John P. and Kraemer, Helena and Spiegel, David. (2009) Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk? Journal of psychiatric research, 43 (16). pp. 1246-1252.

[img] PDF
Restricted to Repository staff only

214Kb

Official URL: http://edoc.unibas.ch/dok/A5250312

Downloads: Statistics Overview

Abstract

To determine if improvement in mood would ameliorate autonomic dysregulation, HPA dysfunction, typical risk factors and C-reactive protein in depressed patients with elevated cardiovascular disease risk (CVD), 48 depressed participants with elevated cardiovascular risk factors were randomized to a cognitive behavioral intervention (CBT) or a waiting list control (WLC) condition. Twenty non-depressed age and risk-matched controls were also recruited. Traditional risk factors (e.g., lipids, blood pressure) and C-reactive protein were assessed pre- and post-treatment six months later. Subjects also underwent a psychophysiological stress test while cardiovascular physiology was measured. Salivary cortisol was measured during the day and during the psychological stress test. At post-treatment, the CBT subjects were significantly less depressed than WLC subjects. There was no significant difference in change scores on any of the traditional risk factors or C-reactive protein, cortisol measures, or cardiovascular physiology, except for triglyceride levels and heart rate, which were significantly lower in treatment compared to control subjects. The normal controls exhibited no change in the variables measured during the same time. A significant improvement in mood may have little impact on most traditional or atypical risk factors, cortisol or cardiophysiology.
Faculties and Departments:07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Abteilung Klinische Psychologie und Psychiatrie
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Psychophysiologie (Wilhelm)
UniBasel Contributors:Wilhelm, Frank H
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Pergamon Press
ISSN:0022-3956
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
Related URLs:
Identification Number:
Last Modified:28 Sep 2017 15:33
Deposited On:22 Mar 2012 13:45

Repository Staff Only: item control page