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Increased high-frequency heart rate variability during insulin-induced hypoglycaemia in healthy humans

Schachinger, Hartmut and Port, Johannes and Brody, Stuart and Linder, Lilly and Wilhelm, Frank H. and Huber, Peter R. and Cox, Daniel and Keller, Ulrich. (2004) Increased high-frequency heart rate variability during insulin-induced hypoglycaemia in healthy humans. Clinical Science, 106 (6). pp. 583-588.

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Abstract

Despite causing sympathetic activation, prolonged hypoglycaemia produces little change in HR (heart rate) in healthy young adults. One explanation could be concurrent parasympathetic activation, resulting in unchanged net effects of autonomic influences. In the present study, hypoglycaemic (2.7 mmol/l) and normoglycaemic (4.7 mmol/l) hyperinsulinaemic clamp studies were performed after normoglycaemic baseline clamp periods with 15 healthy volunteers (seven male; mean age, 27 years) on two occasions in a randomized single-blind cross-over design. Non-invasive indices of cardiac autonomic activity and hormones were measured at baseline and 1 h after the beginning of hypoglycaemia or control normoglycaemia. Plasma insulin levels and mean HR were similar during both conditions. During hypoglycaemia, there was a 485% increase in plasma adrenaline (epinephrine). A shortening of the pre-ejection period by 45% suggested strong sympathetic cardiac activation. High-frequency (0.15-0.45 Hz) HRV (HR variability) increased, indicating a concomitant increase in parasympathetic tone. Thus, during hypoglycaemia-induced sympathetic cardiac activation in healthy adults, parasympathetic mechanisms are involved in stabilizing mean HR.
Faculties and Departments:07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Abteilung Klinische Psychologie und Psychiatrie
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Psychophysiologie (Wilhelm)
UniBasel Contributors:Wilhelm, Frank H and Sch├Ąchinger, Hartmut
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Shaw
ISSN:0009-9287
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Identification Number:
Last Modified:28 Sep 2017 15:39
Deposited On:22 Mar 2012 13:45

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