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End-tidal pCO2 in blood phobics during viewing of emotion- and disease-related films

Ritz, Thomas and Wilhelm, Frank H. and Gerlach, Alexander L. and Kullowatz, Antje and Roth, Walton T.. (2005) End-tidal pCO2 in blood phobics during viewing of emotion- and disease-related films. Psychosomatic medicine, 67 (4). pp. 661-668.

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Abstract

OBJECTIVE: Many patients with blood, injection, and injury (BII) phobia respond to specific stimuli with vasovagal dysregulation and fainting. However, little is known about the role of hyperventilation in the distress of these patients. Hyperventilation, defined by subnormal arterial pCO2 levels, induces anxiety and may promote the development of fainting. We studied end-tidal pCO2 in 12 patients with BII phobia and 14 nonanxious controls during presentation of emotional films. METHOD: Ten film clips were shown, two in each of 5 categories: pleasant, unpleasant, neutral, BII-related (surgery), and asthma-related (portraying labored breathing). For each subject, two subsets were created, each containing one clip from each category. For one subset, the instruction was simply to view the film, and for the other subset, to view the film while tensing the leg muscles. PCO2, heart rate, blood pressure, and leg electromyogram were recorded continuously during viewing, and self-report of symptoms and emotion was collected after each film. RESULTS: Patients reported the greatest anxiety and disgust during surgery films. PCO2 was relatively stable throughout all categories except surgery films, during which minima were below 30 mm Hg, indicating significant hypocapnia. Cardiovascular variables suggested biphasic patterns in two patients with BII phobia. These patients, together with one additional patient and one control who were close to fainting after or during one surgery film, also showed a marked fall in pCO2) Leg muscle tension raised heart rate and systolic blood pressure for all films, but was not related to near-fainting or endurance in surgery film viewing. CONCLUSION: Hyperventilation is part of the fear response of patients with BII phobia, but was transitory in experimental fear induction using surgery films. Its role in real-life exposure and fainting deserves further study.
Faculties and Departments:07 Faculty of Psychology
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Abteilung Klinische Psychologie und Psychiatrie
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Psychophysiologie (Wilhelm)
UniBasel Contributors:Wilhelm, Frank H
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Lippincott Williams & Wilkins
ISSN:0033-3174
Note:Publication type according to Uni Basel Research Database: Journal article
Language:English
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Last Modified:28 Sep 2017 15:28
Deposited On:22 Mar 2012 13:43

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