Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings

Zhou, Kaixin and Asherson, Philip and Sham, Pak and Franke, Barbara and Anney, Richard J. L. and Buitelaar, Jan and Ebstein, Richard and Gill, Michael and Brookes, Keeley and Buschgens, Cathelijne and Campbell, Desmond and Chen, Wai and Christiansen, Hanna and Fliers, Ellen and Gabriëls, Isabel and Johansson, Lena and Marco, Rafaela and Mulas, Fernando and Müller, Ueli and Mulligan, Aisling and Neale, Benjamin M. and Rijsdijk, Fruhling and Rommelse, Nanda and Uebel, Henrik and Psychogiou, Lamprini and Xu, Xiaohui and Banaschewski, Tobias and Sonuga-Barke, Edmund and Eisenberg, Jacques and Manor, Iris and Miranda, Ana and Oades, Robert D. and Roeyers, Herbert and Rothenberger, Aribert and Sergeant, Joseph and Steinhausen, Hans-Christoph and Taylor, Eric and Thompson, Margaret and Faraone, Stephen V.. (2008) Linkage to chromosome 1p36 for attention-deficit/hyperactivity disorder traits in school and home settings. Biological psychiatry, Vol. 64, H. 7. pp. 571-576.

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Official URL: http://edoc.unibas.ch/dok/A5250682

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BACKGROUND: Limited success has been achieved through previous attention-deficit/hyperactivity disorder (ADHD) linkage scans, which were all designed to map genes underlying the dichotomous phenotype. The International Multi-centre ADHD Genetics (IMAGE) project performed a whole genome linkage scan specifically designed to map ADHD quantitative trait loci (QTL). METHODS: A set of 1094 single selected Caucasian ADHD nuclear families was genotyped on a highly accurate and informative single nucleotide polymorphism (SNP) panel. Two quantitative traits measuring the children's symptoms in home and school settings were collected and standardized according to a population sample of 8000 children to reflect the developmental nature and gender prevalence difference of ADHD. Univariate linkage test was performed on both traits and their mean score. RESULTS: A significant common linkage locus was found at chromosome 1p36 with a locus-specific heritability of 5.1% and a genomewide empirical p > .04. Setting-specific suggestive linkage signals were also found: logarithm of odds (LOD) = 2.2 at 9p23 for home trait and LOD = 2.6 at 11q21 for school trait. CONCLUSIONS: These results indicate that given large samples with proper phenotypic measures, searching for ADHD genes with a QTL strategy is an important alternative to using the clinical diagnosis. The fact that our linkage region 1p36 overlaps with the dyslexia QTL DYX8 further suggests it is potentially a pleiotropic locus for ADHD and dyslexia.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:42

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