Righetto, Ricardo D. and Anton, Leonie and Adaixo, Ricardo and Jakob, Roman P. and Zivanov, Jasenko and Mahi, Mohamed-Ali and Ringler, Philippe and Schwede, Torsten and Maier, Timm and Stahlberg, Henning. (2020) High-resolution cryo-EM structure of urease from the pathogen Yersinia enterocolitica. Nature Communications, 11 (1). p. 5101.
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Official URL: https://edoc.unibas.ch/78828/
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Abstract
Urease converts urea into ammonia and carbon dioxide and makes urea available as a nitrogen source for all forms of life except animals. In human bacterial pathogens, ureases also aid in the invasion of acidic environments such as the stomach by raising the surrounding pH. Here, we report the structure of urease from the pathogen Yersinia enterocolitica at 2 Å resolution from cryo-electron microscopy. Y. enterocolitica urease is a dodecameric assembly of a trimer of three protein chains, ureA, ureB and ureC. The high data quality enables detailed visualization of the urease bimetal active site and of the impact of radiation damage. The obtained structure is of sufficient quality to support drug development efforts.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Computational & Systems Biology > Bioinformatics (Schwede) 05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Structural Biology (Stahlberg) 05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Structural Biology (Maier) |
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UniBasel Contributors: | Maier, Timm and Schwede, Torsten and Stahlberg, Henning and Diogo Righetto, Ricardo and Anton, Leonie and Diogo Adaixo, Ricardo Jorge and Jakob, Roman Peter and Zivanov, Jasenko and Mahi, Mohamed-Ali and Ringler, Philippe |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Nature Publishing Group |
e-ISSN: | 2041-1723 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 14 Jan 2022 16:54 |
Deposited On: | 14 Jan 2022 16:54 |
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