Joss, Daniel and Winter, Florine and Häussinger, Daniel. (2020) A novel, rationally designed lanthanoid chelating tag delivers large paramagnetic structural restraints for biomolecular NMR. Chemical Communications , 56 (84). pp. 12673-12870 .
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Abstract
Herein, a novel and rationally designed ortho-substituted pyridine activator is reported that reacts rapidly and selectively with cysteine thiols. It forms reduction-stable conjugates and induces large pseudocontact shifts, residual dipolar couplings and paramagnetic relaxation enhancement on both ubiquitin S57C and human carbonic anhydrase II S50C constructs under physiological conditions.
| Faculties and Departments: | 05 Faculty of Science > Departement Chemie > Chemie > Nuclear Magnetic Resonance (Häussinger) |
|---|---|
| UniBasel Contributors: | Joss, Daniel and Winter, Florine and Häussinger, Daniel |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| e-ISSN: | 1364-548X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Language: | English |
| Identification Number: |
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| edoc DOI: | |
| Last Modified: | 11 Mar 2021 10:43 |
| Deposited On: | 11 Mar 2021 10:43 |
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