Kittur, Nupur and Campbell, Carl H. and Binder, Sue and Shen, Ye and Wiegand, Ryan E. and Mwanga, Joseph R. and Kinung'hi, Safari M. and Musuva, Rosemary M. and Odiere, Maurice R. and Matendechero, Sultani H. and Knopp, Stefanie and Colley, Daniel G.. (2020) Discovering, defining, and summarizing persistent hotspots in SCORE studies. American Journal of Tropical Medicine and Hygiene, 103 (Suppl. 1). pp. 24-29.
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Official URL: https://edoc.unibas.ch/78476/
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Abstract
The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) conducted large field studies on schistosomiasis control and elimination in Africa. All of these studies, carried out in low-, moderate-, and high-prevalence areas, resulted in a reduction in prevalence and intensity of; Schistosoma; infection after repeated mass drug administration (MDA). However, in all studies, there were locations that experienced minimal or no decline or even increased in prevalence and/or intensity. These areas are termed persistent hotspots (PHS). In SCORE studies in medium- to high-prevalence areas, at least 30% of study villages were PHS. There was no consistent relationship between PHS and the type or frequency of intervention, adequacy of reported MDA coverage, and prevalence or intensity of infection at baseline. In a series of small studies, factors that differed between PHS and villages that responded to repeated MDA as expected included sources of water for personal use, sanitation, and hygiene. SCORE studies comparing PHS with villages that responded to MDA suggest the potential for PHS to be identified after a few years of MDA. However, additional studies in different social-ecological settings are needed to develop generalizable approaches that program managers can use to identify and address PHS. This is essential if goals for schistosomiasis control and elimination are to be achieved.
Faculties and Departments: | 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Biostatistics > Bayesian Modelling and Analysis (Vounatsou) 09 Associated Institutions > Swiss Tropical and Public Health Institute (Swiss TPH) > Department of Epidemiology and Public Health (EPH) > Eco System Health Sciences > Helminths and Health (Odermatt) |
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UniBasel Contributors: | Wiegand, Ryan and Knopp, Stefanie |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | American Society of Tropical Medicine and Hygiene |
ISSN: | 0002-9637 |
e-ISSN: | 1476-1645 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 13 Dec 2021 16:45 |
Deposited On: | 13 Dec 2021 16:45 |
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