Luo, Jinghui and Wärmländer, Sebastian K. T. S. and Gräslund, Astrid and Abrahams, Jan Pieter. (2013) Human lysozyme inhibits the in vitro aggregation of Aβ peptides, which in vivo are associated with Alzheimer's disease. Chemical Communications , 49 (58). pp. 6507-6509.
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Official URL: https://edoc.unibas.ch/75910/
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Abstract
Alzheimer's disease is a neurodegenerative disorder characterized by accumulation of A beta peptide aggregates in the brain. Using ThT fluorescence assays, AFM imaging, NMR and CD spectroscopy, and MD modeling we show that lysozyme - a hydrolytic enzyme abundant in human secretions - completely inhibits the aggregation of A beta peptides at equimolar lysozyme : A beta peptide ratios.
| Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Structural Biology & Biophysics > Nano-diffraction of Biological Specimen (Abrahams) |
|---|---|
| UniBasel Contributors: | Abrahams, Jan Pieter |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| e-ISSN: | 1364-548X |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 06 Nov 2020 09:12 |
| Deposited On: | 06 Nov 2020 09:12 |
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