Solinger, Jachen A. and Rashid, Harun-Or and Prescianotto-Baschong, Cristina and Spang, Anne. (2020) FERARI is required for Rab11-dependent endocytic recycling. Nature Cell Biology, 22. pp. 213-224.
|
PDF
- Accepted Version
97Mb |
Official URL: https://edoc.unibas.ch/75402/
Downloads: Statistics Overview
Abstract
Endosomal transport is essential for cellular organization and compartmentalization and cell-cell communication. Sorting endosomes provide a crossroads for various trafficking pathways and determine recycling, secretion or degradation of proteins. The organization of these processes requires membrane-tethering factors to coordinate Rab GTPase function with membrane fusion. Here, we report a conserved tethering platform that acts in the Rab11 recycling pathways at sorting endosomes, which we name factors for endosome recycling and Rab interactions (FERARI). The Rab-binding module of FERARI consists of Rab11FIP5 and rabenosyn-5/RABS-5, while the SNARE-interacting module comprises VPS45 and VIPAS39. Unexpectedly, the membrane fission protein EHD1 is also a FERARI component. Thus, FERARI appears to combine fusion activity through the SM protein VPS45 with pinching activity through EHD1 on SNX-1-positive endosomal membranes. We propose that coordination of fusion and pinching through a kiss-and-run mechanism drives cargo at endosomes into recycling pathways.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Biochemistry (Spang) |
---|---|
UniBasel Contributors: | Spang, Anne |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Nature Publishing Group |
ISSN: | 1465-7392 |
e-ISSN: | 1476-4679 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Language: | English |
Identification Number: |
|
edoc DOI: | |
Last Modified: | 27 Jul 2020 01:30 |
Deposited On: | 04 Feb 2020 12:24 |
Repository Staff Only: item control page