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Flickerlichtprovokation bei Vasospastikern verglichen mit gesunden Kontrollpersonen

Rickenbacher, I. and Gugleta, K. and Zawinka, C. and Schötzau, A. and Katamay, R. and Flammer, J. and Orgül, S.. (2009) Flickerlichtprovokation bei Vasospastikern verglichen mit gesunden Kontrollpersonen. Klinische Monatsblätter für Augenheilkunde, Vol. 226, H. 4. pp. 305-309.

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Official URL: http://edoc.unibas.ch/dok/A5252354

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Abstract

BACKGROUND: Vascular dysregulation is considered to be a risk factor in several ophthalmic diseases. The purpose of this study was to evaluate the reaction of retinal vessels to flicker light in otherwise healthy subjects with a vasospastic propensity. PATIENTS AND METHODS: Thirty healthy Caucasians, aged between 18-35 years were recruited for this study and grouped into vasospastics, based on a history of frequent cold hands, even in summer, with concordant findings in nailfold capillary microscopy, or as controls, if such a history was absent. The reaction of the retinal vascular diameter to flicker light was observed in a distance of two to three discs diameters away from the optic nerve head with the retinal vessel analyser. Three phases of flicker light of twenty seconds followed by baseline light phases of eighty seconds were recorded. The maximal vasodilatory amplitude of each flicker phase was determined and the results averaged. RESULTS: The maximal average dilatory amplitude at the arterial side reached (mean +/- SD) 2.9 +/- 1.7 % and 4.8 +/- 2.6 % of the baseline amplitude respectively in vasospastic subjects and in healthy controls (t = 2.34; p = 0.025). The reaction at the venous side was statistically comparable in both groups. CONCLUSIONS: Otherwise healthy, vasospastic subject disclosed an altered reaction of the retinal vasculature to flicker light in this study.
Faculties and Departments:03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Ophthalmologie (Flammer)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ehemalige Einheiten Spezialfächer (Klinik) > Ophthalmologie (Flammer)
03 Faculty of Medicine > Bereich Spezialfächer (Klinik) > Ophthalmologie USB > Ophthalmologie (Orgül)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Spezialfächer (Klinik) > Ophthalmologie USB > Ophthalmologie (Orgül)
UniBasel Contributors:Flammer, Josef and Orgül, Selim and Gugleta, Konstantin
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Thieme
ISSN:0023-2165
Note:Variant title: Response of retinal vessel diameter to flicker-light in vasospastics compared to healthy controls -- Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Feb 2013 08:45
Deposited On:22 Mar 2012 13:39

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