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Enhancing exposure therapy for anxiety disorders with glucocorticoids : from basic mechanisms of emotional learning to clinical applications

Bentz, D. and Michael, T. and De Quervain, D. and Wilhelm, F. H.. (2010) Enhancing exposure therapy for anxiety disorders with glucocorticoids : from basic mechanisms of emotional learning to clinical applications. Journal of anxiety disorders, 24 (2). pp. 223-230.

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Official URL: http://edoc.unibas.ch/dok/A5254542

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Abstract

Current neurophysiological and psychological accounts view exposure therapy as the clinical analog of extinction learning that results in persistent modifications of the fear memory involved in the pathogenesis, symptomatology, and maintenance of anxiety disorders. Evidence from studies in animals and humans indicate that glucocorticoids have the potential to facilitate the processes that underlie extinction learning during exposure therapy. Particularly, glucocorticoids can restrict retrieval of previous aversive learning episodes and enhance consolidation of memory traces relating to non-fearful responding in feared situations. Thus, glucocorticoid treatment especially in combination with exposure therapy might be a promising approach to optimize treatment of anxiety disorders. This review examines the processes involved in aversive conditioning, fear learning and fear extinction, and how glucocorticoids might enhance restructuring of fear memories during therapy.
Faculties and Departments:03 Faculty of Medicine > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
03 Faculty of Medicine > Departement Klinische Forschung > Bereich Psychiatrie (Klinik) > Erwachsenenpsychiatrie UPK > Kognitive Neurowissenschaften (de Quervain)
07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Psychophysiologie (Wilhelm)
07 Faculty of Psychology > Departement Psychologie > Forschungsbereich Klinische Psychologie und Neurowissenschaften > Cognitive Neuroscience (de Quervain)
UniBasel Contributors:Wilhelm, Frank H and de Quervain, Dominique J.-F. and Bentz, Dorothee
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0887-6185
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:19 Jun 2018 15:23
Deposited On:22 Mar 2012 13:38

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