Mühlebach, S. and Steger, P. and Conen, D. and Wyss, P. A.. (1996) Erfolgreiche Therapie akuter Salizylatintoxikationen mit Glycin und Aktivkohle. Schweizerische Medizinische Wochenschrift, 126 (49). pp. 2127-2129.
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Official URL: https://edoc.unibas.ch/72510/
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Abstract
Acute intoxications with salicylates are common. In a dosage of 150-300 mg/kg they are severe, and above 500 mg/kg potentially fatal. To commit suicide 4 patients ingested 375-460 mg/kg acetylsalicylic acid; 3-8 hours after ingestion salicylate blood levels of up to 760 mg/l were observed. The patients were treated for a period of 16 hours with oral charcoal and glycine (1 g/kg initially, followed every 4 hours by 0.5 g/kg, and 8 g initially, followed by 4 g, respectively). To increase urinary pH (7-9) they received i.v. NaHCO3. Blood levels of salicylic acid including its metabolites dropped initially with a virtual half-life of 2-4 hours. 18 hours after hospital admission every patient was in good general condition; none of them required hemodialysis. The urinary excretion of total salicylate reached only 6-14% of the dose within the first 12 hours of therapy, clearly indicating the importance of combined therapy with glycine and charcoal in achieving a good clinical outcome.
Faculties and Departments: | 05 Faculty of Science > Departement Pharmazeutische Wissenschaften > Pharmazie > Clinical Pharmacy (Meier) |
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UniBasel Contributors: | Mühlebach, Stefan F |
Item Type: | Article, refereed |
Article Subtype: | Further Journal Contribution |
Publisher: | Schwabe |
ISSN: | 0036-7672 |
Note: | Publication type according to Uni Basel Research Database: Journal item |
Last Modified: | 29 Nov 2021 10:20 |
Deposited On: | 29 Nov 2021 10:20 |
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