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Tonotopic organization of the human auditory cortex as detected by BOLD-FMRI

Bilecen, D. and Scheffler, K. and Schmid, N. and Tschopp, K. and Seelig, J.. (1998) Tonotopic organization of the human auditory cortex as detected by BOLD-FMRI. Hearing Research, 126 (1-2). pp. 19-27.

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Official URL: http://edoc.unibas.ch/dok/A5257422

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Abstract

Functional magnetic resonance imaging is a noninvasive and nonradioactive method for the detection of focal brain activity. In the present study the auditory cortex was investigated in nine normal subjects who were binaurally stimulated using pulsed sine tones of 500 Hz and 4000 Hz. The BOLD (blood oxygenation level dependent) signal change coincided with the stimulation paradigm and was detected in the plane of the superior temporal gyrus. The comparison of the spatial distribution of activated areas revealed a different behavior for the two frequencies. The present findings underline the existence of a frequency specific organization in the medio-lateral, fronto-occipital and cranio-caudal extension in both hemispheres of the auditory cortex in human. The activated areas for the high tone were found more frontally and medially orientated than the low tone stimulated areas. Furthermore, a slight cranio-caudal shift was observed for the higher frequency, more pronounced in the right than in the left temporal lobe. Finally, for most of the subjects investigated the BOLD activation area of the 500 Hz sine tone was larger than that of the 4000 Hz stimulation. Both frequencies showed a lateralization of signal response to the left temporal lobe.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Former Organization Units Biozentrum > Biophysical Chemistry (Seelig J)
UniBasel Contributors:Seelig, Joachim
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Elsevier
ISSN:0378-5955
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:14 Nov 2017 15:10
Deposited On:22 Mar 2012 13:38

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