Zuberbier, T. and Schwarz, S. and Hartmann, K. and Pfrommer, C. and Czarnetzki, B. M.. (1996) Histamine releasability of basophils and skin mast cells in chronic urticaria. Allergy, 51 (1). pp. 24-28.
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Official URL: https://edoc.unibas.ch/70868/
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Abstract
In order to clarify the pathogenetic role of basophils and mast cells in chronic urticaria, histamine and leukotriene (LT)C4 release was examined in washed mixed leukocytes (n = 8) and skin mast cells (n = 5) from patients with chronic urticaria and compared with the same cells from normal controls (n = 9). Anti-IgE-stimulated basophil histamine release was significantly reduced in urticaria patients (median 2.9% vs 15.1% in normal controls), whereas histamine release to A23187, FMLP, and PAF, as well as anti-IgE-induced LTC4 release, showed no differences in both groups. In contrast, anti-IgE-stimulated skin mast cells from urticaria patients reacted similarly to those of controls (median histamine release 11.4% vs 14.2% in normal controls). Pretreatment of the cells with interleukin (IL)-3 upregulated responsiveness of basophil histamine release to anti-IgE in urticaria patients (median histamine release 14.3%), but pretreatment with the H2-antagonist cimetidine showed no effect. These data show that reduced basophil histamine releasability in chronic urticaria is not H2 mediated. It is a stimulus-, mediator-, and cell type-restricted phenomenon that can, at least partially, be reversed in the presence of the cytokine IL-3.
Faculties and Departments: | 03 Faculty of Medicine > Departement Biomedizin > Department of Biomedicine, University Hospital Basel > Allergy and Immunity (Hartmann) |
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UniBasel Contributors: | Hartmann, Karin |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Munksgaard |
ISSN: | 0105-4538 |
e-ISSN: | 1398-9995 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 10 Nov 2020 14:26 |
Deposited On: | 10 Nov 2020 14:26 |
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