A map of the interactome network of the metazoan C. elegans

Li, Siming and Armstrong, Christopher M. and Bertin, Nicolas and Ge, Hui and Milstein, Stuart and Boxem, Mike and Vidalain, Pierre-Olivier and Han, Jing-Dong J. and Chesneau, Alban and Hao, Tong and Goldberg, Debra S. and Li, Ning and Martinez, Monica and Rual, Jean-François and Lamesch, Philippe and Xu, Lai and Tewari, Muneesh and Wong, Sharyl L. and Zhang, Lan V. and Berriz, Gabriel F. and Jacotot, Laurent and Vaglio, Philippe and Reboul, Jérôme and Hirozane-Kishikawa, Tomoko and Li, Qianru and Gabel, Harrison W. and Elewa, Ahmed and Baumgartner, Bridget and Rose, Debra J. and Yu, Haiyuan and Bosak, Stephanie and Sequerra, Reynaldo and Fraser, Andrew and Mango, Susan E. and Saxton, William M. and Strome, Susan and Van Den Heuvel, Sander and Piano, Fabio and Vandenhaute, Jean and Sardet, Claude and Gerstein, Mark and Doucette-Stamm, Lynn and Gunsalus, Kristin C. and Harper, J. Wade and Cusick, Michael E. and Roth, Frederick P. and Hill, David E. and Vidal, Marc. (2004) A map of the interactome network of the metazoan C. elegans. Science, 303 (5657). pp. 540-543.

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Official URL: https://edoc.unibas.ch/70577/

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Abstract

To initiate studies on how protein-protein interaction (or "interactome") networks relate to multicellular functions, we have mapped a large fraction of the Caenorhabditis elegans interactome network. Starting with a subset of metazoan-specific proteins, more than 4000 interactions were identified from high-throughput, yeast two-hybrid (HT=Y2H) screens. Independent coaffinity purification assays experimentally validated the overall quality of this Y2H data set. Together with already described Y2H interactions and interologs predicted in silico, the current version of the Worm Interactome (WI5) map contains approximately 5500 interactions. Topological and biological features of this interactome network, as well as its integration with phenome and transcriptome data sets, lead to numerous biological hypotheses.

Faculties and Departments:	05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango)
UniBasel Contributors:	Mango, Susan Elizabeth
Item Type:	Article, refereed
Article Subtype:	Research Article
Publisher:	American Association for the Advancement of Science
ISSN:	0036-8075
e-ISSN:	1095-9203
Note:	Publication type according to Uni Basel Research Database: Journal article
Related URLs:	Green Open Access
Identification Number:	doi: 10.1126/science.1091403 pmid: 14704431
Last Modified:	13 Nov 2020 09:51
Deposited On:	13 Nov 2020 09:51

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