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Trace amine-associated receptor 1 modulates dopaminergic activity

Lindemann, Lothar and Meyer, Claas Aiko and Jeanneau, Karine and Bradaia, Amyaouch and Ozmen, Laurence and Bluethmann, Horst and Bettler, Bernhard and Wettstein, Joseph G. and Borroni, Edilio and Moreau, Jean-Luc and Hoener, Marius C.. (2008) Trace amine-associated receptor 1 modulates dopaminergic activity. Journal of pharmacology and experimental therapeutics, Vol. 324, H. 3. pp. 948-956.

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Official URL: http://edoc.unibas.ch/dok/A5262215

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Abstract

The recent identification of the trace amine-associated receptor (TAAR)1 provides an opportunity to dissociate the effects of trace amines on the dopamine transporter from receptor-mediated effects. To separate both effects on a physiological level, a Taar1 knockout mouse line was generated. Taar1 knockout mice display increased sensitivity to amphetamine as revealed by enhanced amphetamine-triggered increases in locomotor activity and augmented striatal release of dopamine compared with wild-type animals. Under baseline conditions, locomotion and extracellular striatal dopamine levels were similar between Taar1 knockout and wild-type mice. Electrophysiological recordings revealed an elevated spontaneous firing rate of dopaminergic neurons in the ventral tegmental area of Taar1 knock-out mice. The endogenous TAAR1 agonist p-tyramine specifically decreased the spike frequency of these neurons in wild-type but not in Taar1 knockout mice, consistent with the prominent expression of Taar1 in the ventral tegmental area. Taken together, the data reveal TAAR1 as regulator of dopaminergic neurotransmission.
Faculties and Departments:03 Faculty of Medicine > Departement Biomedizin > Division of Physiology > Molecular Neurobiology Synaptic Plasticity (Bettler)
UniBasel Contributors:Bettler, Bernhard
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Williams and Wilkins
ISSN:0022-3565
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:01 Mar 2013 11:07
Deposited On:22 Mar 2012 13:37

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