Choi, Youngeun and Mango, Susan E.. (2014) Hunting for Darwin's gemmules and Lamarck's fluid: transgenerational signaling and histone methylation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1839 (12). pp. 1440-1453.
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Official URL: https://edoc.unibas.ch/70548/
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Abstract
Recent studies have discovered phenotypes induced by a transient treatment or mutation that persist for multiple generations without mutations in DNA. Both invertebrates and vertebrates exhibit such inheritance, and a range of environmental factors can act as a trigger. Now referred to as transgenerational epigenetic inheritance or TEI, this emerging field faces a big challenge-what molecular mechanisms account for inheritance of TEI phenotypes? This review describes examples of TEI and focuses on the possible role of histone methylation and small RNAs in mediating TEI.
Faculties and Departments: | 05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango) |
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UniBasel Contributors: | Mango, Susan Elizabeth |
Item Type: | Article, refereed |
Article Subtype: | Research Article |
Publisher: | Elsevier |
ISSN: | 0006-3002 |
Note: | Publication type according to Uni Basel Research Database: Journal article |
Identification Number: |
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Last Modified: | 16 Nov 2020 10:01 |
Deposited On: | 16 Nov 2020 10:01 |
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