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Hunting for Darwin's gemmules and Lamarck's fluid: transgenerational signaling and histone methylation

Choi, Youngeun and Mango, Susan E.. (2014) Hunting for Darwin's gemmules and Lamarck's fluid: transgenerational signaling and histone methylation. Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1839 (12). pp. 1440-1453.

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Official URL: https://edoc.unibas.ch/70548/

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Abstract

Recent studies have discovered phenotypes induced by a transient treatment or mutation that persist for multiple generations without mutations in DNA. Both invertebrates and vertebrates exhibit such inheritance, and a range of environmental factors can act as a trigger. Now referred to as transgenerational epigenetic inheritance or TEI, this emerging field faces a big challenge-what molecular mechanisms account for inheritance of TEI phenotypes? This review describes examples of TEI and focuses on the possible role of histone methylation and small RNAs in mediating TEI.
Faculties and Departments:05 Faculty of Science > Departement Biozentrum > Growth & Development > Cell and Developmental Biology (Mango)
UniBasel Contributors:Mango, Susan Elizabeth
Item Type:Article, refereed
Article Subtype:Research Article
Publisher:Elsevier
ISSN:0006-3002
Note:Publication type according to Uni Basel Research Database: Journal article
Identification Number:
Last Modified:16 Nov 2020 10:01
Deposited On:16 Nov 2020 10:01

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