Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder

Zhou, Kaixin and Dempfle, Astrid and Arcos-Burgos, Mauricio and Bakker, Steven C. and Banaschewski, Tobias and Biederman, Joseph and Buitelaar, Jan and Castellanos, F. Xavier and Doyle, Alysa and Ebstein, Richard P. and Ekholm, Jenny and Forabosco, Paola and Franke, Barbara and Freitag, Christine and Friedel, Susann and Gill, Michael and Hebebrand, Johannes and Hinney, Anke and Jacob, Christian and Lesch, Klaus Peter and Loo, Sandra K. and Lopera, Francisco and McCracken, James T. and McGough, James J. and Meyer, Jobst and Mick, Eric and Miranda, Ana and Muenke, Maximilian and Mulas, Fernando and Nelson, Stanley F. and Nguyen, T. Trang and Oades, Robert D. and Ogdie, Matthew N. and Palacio, Juan David and Pineda, David and Reif, Andreas and Renner, Tobias J. and Roeyers, Herbert and Romanos, Marcel and Rothenberger, Aribert and Schäfer, Helmut and Sergeant, Joseph and Sinke, Richard J. and Smalley, Susan L. and Sonuga-Barke, Edmund and Steinhausen, Hans-Christoph and van der Meulen, Emma and Walitza, Susanne and Warnke, Andreas and Lewis, Cathryn M. and Faraone, Stephen V. and Asherson, Philip. (2008) Meta-analysis of genome-wide linkage scans of attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 147B, H. 8. pp. 1392-1398.

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Official URL: http://edoc.unibas.ch/dok/A5250660

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Genetic contribution to the development of attention deficit hyperactivity disorder (ADHD) is well established. Seven independent genome-wide linkage scans have been performed to map loci that increase the risk for ADHD. Although significant linkage signals were identified in some of the studies, there has been limited replications between the various independent datasets. The current study gathered the results from all seven of the ADHD linkage scans and performed a Genome Scan Meta Analysis (GSMA) to identify the genomic region with most consistent linkage evidence across the studies. Genome-wide significant linkage (P(SR) = 0.00034, P(OR) = 0.04) was identified on chromosome 16 between 64 and 83 Mb. In addition there are nine other genomic regions from the GSMA showing nominal or suggestive evidence of linkage. All these linkage results may be informative and focus the search for novel ADHD susceptibility genes.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

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