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Parent of origin effects in attention/deficit hyperactivity disorder (ADHD) : analysis of data from the international multicenter ADHD genetics (IMAGE) program

Anney, Richard J. L. and Hawi, Ziarih and Sheehan, Karen and Mulligan, Aisling and Pinto, Carlos and Brookes, Keeley J. and Xu, Xiaohui and Zhou, Kaixin and Franke, Barbara and Buitelaar, Jan and Vermeulen, Sita H. and Banaschewski, Tobias and Sonuga-Barke, Edmund and Ebstein, Richard and Manor, Iris and Miranda, Ana and Mulas, Fernando and Oades, Robert D. and Roeyers, Herbert and Rommelse, Nanda and Rothenberger, Aribert and Sergeant, Joseph and Steinhausen, Hans-Christoph and Taylor, Eric and Thompson, Margaret and Asherson, Philip and Faraone, Stephen V. and Gill, Michael. (2008) Parent of origin effects in attention/deficit hyperactivity disorder (ADHD) : analysis of data from the international multicenter ADHD genetics (IMAGE) program. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 147B, H. 8. pp. 1495-1500.

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Official URL: http://edoc.unibas.ch/dok/A5250690

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Abstract

There are conflicting reports suggesting that the parental origin of transmitted risk alleles may play a role in the etiology of attention deficit/hyperactivity disorder (ADHD). A recent report by Hawi and colleagues observed a generalized paternal over-transmission of alleles associated with ADHD. This was not replicated in more recent studies. Using data from a large multicenter study we examined the overall and gene-specific parent of origin effect in 554 independent SNPs across 47 genes. Transmission disequilibrium and explicit parent of origin test were performed using PLINK. Overall parent of origin effect was tested by Chi-square. There was no overall parent of origin effect in the IMAGE sample (chi(1)(2) = 1.82, P = 0.117). Five markers in three genes, DDC, TPH2, and SLC6A2 showed nominal association (P > 0.01) with ADHD combined subtype when restricted to maternal or paternal transmission only. Following the initial report by Hawi and co-workers three studies, including this one, found no evidence to support an overall parent of origin effect for markers associated with ADHD. We cannot however, exclude gene-specific parent of origin effect in the etiology ADHD.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

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