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Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder

Lasky-Su, Jessica and Anney, Richard J. L. and Neale, Benjamin M. and Franke, Barbara and Zhou, Kaixin and Maller, Julian B. and Vasquez, Alejandro Arias and Chen, Wai and Asherson, Philip and Buitelaar, Jan and Banaschewski, Tobias and Ebstein, Richard and Gill, Michael and Miranda, Ana and Mulas, Fernando and Oades, Robert D. and Roeyers, Herbert and Rothenberger, Aribert and Sergeant, Joseph and Sonuga-Barke, Edmund and Steinhausen, Hans Christoph and Taylor, Eric and Daly, Mark and Laird, Nan and Lange, Christoph and Faraone, Stephen V.. (2008) Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol. 147B, H. 8. pp. 1355-1358.

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Official URL: http://edoc.unibas.ch/dok/A5250666

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Abstract

A time-to-onset analysis for family-based samples was performed on the genomewide association (GWAS) data for attention deficit hyperactivity disorder (ADHD) to determine if associations exist with the age at onset of ADHD. The initial dataset consisted of 958 parent-offspring trios that were genotyped on the Perlegen 600,000 SNP array. After data cleaning procedures, 429,981 autosomal SNPs and 930 parent-offspring trios were used found suitable for use and a family-based logrank analysis was performed using that age at first ADHD symptoms as the quantitative trait of interest. No SNP achieved genome-wide significance, and the lowest P-values had a magnitude of 10(-7). Several SNPs among a pre-specified list of candidate genes had nominal associations including SLC9A9, DRD1, ADRB2, SLC6A3, NFIL3, ADRB1, SYT1, HTR2A, ARRB2, and CHRNA4. Of these findings SLC9A9 stood out as a promising candidate, with nominally significant SNPs in six distinct regions of the gene.
Faculties and Departments:07 Faculty of Psychology > Departement Psychologie > Ehemalige Einheiten Psychologie > Clinical Child and Adolescent Psychology (Schneider)
UniBasel Contributors:Steinhausen, Hans-Christoph
Item Type:Article, refereed
Article Subtype:Research Article
Bibsysno:Link to catalogue
Publisher:Wiley-Liss
ISSN:1552-4841
Note:Publication type according to Uni Basel Research Database: Journal article
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Last Modified:22 Mar 2012 14:24
Deposited On:22 Mar 2012 13:37

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