Bleiber, Gabriela and May, Margaret and Suarez, Carlos and Martinez, Raquel and Marzolini, Catia and Egger, Matthias and Telenti, Amalio and Swiss HIV Cohort Study, . (2004) MDR1 genetic polymorphism does not modify either cell permissiveness to HIV-1 or disease progression before treatment. Journal of Infectious Diseases, 189 (4). pp. 583-586.
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Official URL: https://edoc.unibas.ch/69541/
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Abstract
Nonphysiological overexpression of the ABC transporter P-glycoprotein (P-gp), which is encoded by MDR1, has been associated with reduced susceptibility to human immunodeficiency virus (HIV) type 1 infection in vitro. We analyzed (1) the expression and genotype of MDR1 and their relationship to HIV-1 permissiveness of CD4+ T cells from 128 healthy blood donors and (2) the role that alleles of MDR1 exons 21 and 26 play in modifying disease progression in 411 HIV-1-infected individuals. Differences in physiological levels of MDR1 expression did not modify HIV-1 infection in vitro, nor did MDR1 alleles and haplotypes significantly influence either permissiveness to infection in vitro or disease progression in vivo before the initiation of treatment.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M) |
|---|---|
| UniBasel Contributors: | Marzolini, Catia |
| Item Type: | Article, refereed |
| Article Subtype: | Research Article |
| Publisher: | Oxford University Press |
| ISSN: | 0022-1899 |
| e-ISSN: | 1537-6613 |
| Note: | Publication type according to Uni Basel Research Database: Journal article |
| Identification Number: |
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| Last Modified: | 16 Nov 2020 12:55 |
| Deposited On: | 16 Nov 2020 12:55 |
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