de Roche, Mirjam and Siccardi, Marco and Stoeckle, Marcel and Livio, Françoise and Back, David and Battegay, Manuel and Marzolini, Catia. (2012) Efavirenz in an obese HIV-infected patient - a report and an in vitro-in vivo extrapolation model indicate risk of underdosing. Antiviral Therapy, 17 (7). pp. 1381-1384.
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Official URL: https://edoc.unibas.ch/69522/
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Abstract
Here, we report suboptimal efavirenz exposure in an obese patient treated with the standard 600 mg dose. Tripling the dose allowed attainment of therapeutic efavirenz concentrations. We developed an in vitro-in vivo extrapolation model to quantify dose requirements in obese individuals. Obesity represents a risk factor for antiretroviral therapy underdosing.
| Faculties and Departments: | 03 Faculty of Medicine > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M) 03 Faculty of Medicine > Departement Klinische Forschung > Bereich Medizinische Fächer (Klinik) > Infektiologie > Infektiologie (Battegay M) |
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| UniBasel Contributors: | Marzolini, Catia |
| Item Type: | Article, refereed |
| Article Subtype: | Further Journal Contribution |
| Publisher: | International Medical Press |
| ISSN: | 1359-6535 |
| e-ISSN: | 2040-2058 |
| Note: | Publication type according to Uni Basel Research Database: Journal item |
| Related URLs: | |
| Identification Number: |
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| Last Modified: | 08 Jul 2020 06:53 |
| Deposited On: | 01 Jul 2020 12:50 |
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